After Birth Ebook

Getting Back Into Shape After The Pregnancy

Getting Back Into Shape After The Pregnancy

Once your pregnancy is over and done with, your baby is happily in your arms, and youre headed back home from the hospital, youll begin to realize that things have only just begun. Over the next few days, weeks, and months, youre going to increasingly notice that your entire life has changed in more ways than you could ever imagine.

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Pregnancy Without Pounds

This proven program will get you through your pregnancy in better shape than most other women in as little as 27 minutes a day and with minimal effort. It contains all the information that I believe will Help you to look and feel like I did barefoot and beautiful! Inside you will learn Exactly how to avoid unwanted pounds, overcome your food cravings, care for your skin, dress to kill and look like one Hot Mama. Ive also put together Fifty simple, yet extremely effective pregnancy-friendly exercises and stretches to keep you and your body looking and feeling Great (includes 3 different fitness programs depending on Your fitness level)!

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Author: Michelle Moss
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Recently several visitors of blog have asked me about this manual, which is being advertised quite widely across the Internet. So I decided to buy a copy myself to find out what all the excitement was about.

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Copper In Diseases And Genetic Diseases Of Copper Metabolism

The genetic bases of these two major diseases of copper transport were uncovered by several research groups in the early 1990s. First, the gene responsible for Menkes disease (and the less severe occipital horn syndrome) was cloned (173-175) in 1993, then that for Wilson disease (176,177). As already described in some detail in earlier sections of this review, the corresponding normal proteins encoded by these genes are both P-type ATPases (ATP7B and 7A, for WND and MNK, respectively). They are usually expressed in different cell types (MNK quite widely, and WND primarily in hepatocytes and certain areas of the brain) located in the trans-Golgi network and vesicular compartments (Figs. 1, 3, and 4), they can be translocated to the plasma membrane under conditions when copper secretion or efflux needs to be promoted. Menkes disease results in abnormal gestational development and a copper-deficient phenotype, because of reduced copper transport to the fetus (via the placenta) as well as...

Useful Parameters and Landmarks

Growth velocity is most rapid immediately after birth and up to three years of age, after which there is a continued deceleration of growth until puberty. The adolescent growth peak in girls is at approximately 12 years, and in boys at approximately 14 years of age. It is useful to compare growth at yearly intervals, although in infancy shorter time intervals will be used because the velocity is greater.

Behavior And Reproduction

At the time of its first breeding the procellariid is usually around five or six years old. One egg is laid, and both parents take turns sitting on it in shifts lasting two to fourteen days. This goes on for six to nine weeks, depending on the species, and then the egg hatches. Parents care for the chick but leave it as soon as it is able to control its own body temperature, which is anywhere from two to twenty days after birth. At that time, parents visit the chick only at feeding time. A week or two after the parents leave, the chick heads out to sea.

Reproductive biology

In most species, the female leaves the herd or family group to give birth. Most species produce relatively helpless young that lie hidden for a period varying from only 1-2 days (impala) to two months or more (reedbucks). However, female wildebeest bear calves within the herd and the young can run a few minutes after birth. Young tsessebe (Damaliscus l. luna-tus) are also able to keep up with the herd from shortly after birth.

Genotoxicity and Potential for Carcinogenesis

One major concern for retroviral vectors including lentivirus is, that inappropriate retroviral integration might lead to insertional mutagenesis and malignancies. This concern was heightened following the development of fatal lymphomas in 3 out of 10 rhesus macaque recipients of bone marrow cells contaminated with RCR (124). It should be noted that the macaques that developed malignancies were severely immunocompro-mised, and similar experiments using less severe immunosuppression showed no evidence of any pathology resulting from systemic inoculation of wild type MMLV (125,126). Nonetheless, the potential for such adverse events now has clinical precedent (127), with recent reports of clonal T-cell proliferation in 2 out of 11 immunodeficient pediatric patients emerging more than 2 yr after correction of interleukin receptor common y-chain deficiency SCID. This serious adverse event has caused major effect on clinical gene therapy trials worldwide. As described above, in this trial,...

C HIT in Children and Neonates

Platelet aggregation studies, reported a neonate who may have developed fatal HIT shortly after birth. More specific activation or antigen assays were not performed in either study, however. A recent study of 108 neonates who received UFH flushes found no HIT antibodies using a sensitive antigen assay (Klenner et al., 2003).

Head Circumference OFC

Although height and weight charts after birth are quite different for North American and North European populations, head circumference growth data after birth are not. Therefore, we have included only one figure for head circumference for each sex. We have added charts depicting neonatal head circumference size for North European males and females because these charts include earlier gestational ages compared to the data by Lubchenko et al. (Figs. 6.2-6.4)

Other dairy products to improve infant health

Infant formulas or so called breast milk substitutes aim to provide an efficient and safe alternative diet for infants of those women who are not able to continue breastfeeding until six months of life. Infant formula can be fed directly after birth when breastfeeding is not possible follow-on formulas are designed for children after the sixth month of life. Breast milk substitutes aim to mimic the composition of human breast milk concerning protein, fat and carbohydrate composition. The only carbohydrate of infant formulas is lactose, whereas follow-on formulas contain other carbohydrates, too. Protein sources are mainly bovine whey or casein (in the standard cow's milk based formulas) or soy protein (for infants with lactose intolerance or cow milk protein allergy). The quality parameter for the evaluation of infant diets is the ability to allow normal physical growth as well as optimal neurological and mental development.

JCAHO Infection Control Guidelines

6 Ignaz Philipp Semmelweis (1818-65), a Hungarian obstetrician, introduced antiseptic prophylaxis into medicine. In the 1840s, puerperal or childbirth fever, a bacterial infection of the female genital tract after childbirth, was taking the lives of up to 30 of women who gave birth in hospitals. Women who gave birth at home remained relatively unaffected. Semmelweis observed that women examined by student doctors who had not washed their hands after leaving the autopsy room had very high death rates. When a colleague who had received a scalpel cut died of infection, Semmelweis concluded that puerperal fever was septic and contagious. He ordered students to wash their hands with chlorinated lime before examining patients as a result, the maternal death rate in his hospital was reduced from 12 to 1 in two years. Source Copyright 1999,2000.

Distribution of GSK3 in Neurons

Ground-breaking immunohistochemical studies showed that GSK-3 is mainly present in neurons, and interestingly it was found in growing axons 11 . However, in mature tissue it appears that GSK-3 becomes restricted to the gray matter. These studies showed that the developmental profiles of GSK-3 a and GSK-3 p expression are different and in particular, that the p isoform is downregulated after birth.

Congenital General Anosmia

To date, no causative genes have been described for isolated human CGA. However in mouse, three transduction genes have revealed behavioral phenotypes consistent with general anosmia when they are inactivated. Mice generated by homologous recombination, lacking the functional olfactory cyclic nucleotide-gated channel (Cnga2) (45), the stimulatory olfactory G-protein (Gnal), (46) or enzyme adenylyl cyclase III (Adcy3) (47), display profound reductions or even absence of physiological responses to odorants. Most ofthe homozygously deficient mice die within a few days after birth owing to an apparent inability to locate their mother's nipple and suckle.

Alternative Sites for Immune Responses

GALT architecture is not fully developed at birth and needs further maturation to become a specific niche for a functional mucosal adaptive immune system. In mesenteric LNs, the formation of cortex and medulla as well as segregation into B and T cell compartments develop during the first week after birth (Cupedo et al. 2004a). GCs as well as FDC networks are not fully established before 1-2 weeks after birth (Balogh et al. 2002 Pihlgren et al. 2003).

Postnatal development

Eventually, provision of milk by the mother comes to an end and the offspring are weaned. In altricial mammal species, there is usually a fairly constant lactation period, and weaning tends to occur within a few weeks after birth. In preco-cial mammals, the lactation period can be quite variable and it may last months or even years. In fact, there is some indication that for certain hoofed mammals and primates there is a feedback relationship between the frequency of suckling and the mother's resumption of fertility, driven by the level of maternal nutrition. If food availability is low, the mother produces more dilute milk, which results in an increased suckling frequency. A higher frequency of suckling can suppress maternal fertility and also lead to an extension of the lactation period.

Activation of the Intestinal Immune System

As in the neonate, the intestinal IgA-secreting cell (IgA-SC) number is much reduced in adult GF mice. Three weeks after bacterial colonization of the intestine, GF mice have an IgA-SC number equivalent to that found in CV mice. In the young, the adult number of IgA-SC is reached at the age of 6 weeks in mice and between 1 and 2 years in babies (7). This important delay might be attributed to the immaturity of the IIS of the newborn and or the suppressive effect of Abs present in the mother's milk. However, it might also be due to the stimulatory effect of the intestinal microbiota that has been established according to a sequential manner from birth to after weaning as described previously. To test the later hypothesis, several models of adult gnotobiotic mice were colonized by the entire digestive microbiota obtained from growing CV mice from one day after birth to 25 days of age (i.e., 6 days after weaning 62). In these experimental adult models, the effect of maternal milk, and...

Regulation of the Immune Responses

It is interesting to compare these experimental results to those described in human neonates by Lodinova-Zadnikova and coworkers (85). In their study, they colonized the digestive tract of babies just after birth with a given strain of E. coli. In these conditions E. coli is able to establish durably in the digestive tract of newborns as described previously (86). After 10 years (preterm infants) and 20 years (full-term infants), differences in occurrence of food allergies between colonized and control subjects were statistically significant 21 versus 53 , and 36 versus 51 respectively. Furthermore, recent clinical trials using ingestion of a strain of probiotic, Lactobacillus rhamnosus GG, during the last month of pregnancy to women and after birth to babies during 6 months, reduced the incidence of atopic eczema in at-risk children during the first 4 years of life (87). However, in this case, IgE levels were not decreased in the treated group as compared with the placebo group. The...

Mammalian reproduction

Reproduction is pivotal to the continuation of life. From an evolutionary standpoint, there is no single factor that has more impact on the development of species. The impetus to reproduce shapes morphology, physiology, life history, and behavior of all animals, mammals included. From the egg-laying platypus (Ornithorhynchus anatinus) to the wildebeests (genus Connochaetes) that have neonates that can run mere seconds after birth, a wide variety of strategies have evolved to successfully bear offspring in a multitude of environments.

Isolated Lymphoid Follicles

ILFs are small, solitary follicles localized below a FAE at the antimesenteric site of the small intestine (Hamada et al. 2002) (Fig. 1C). In addition, ILFs are found in the large intestine of mice (Kweon et al. 2005 Owen et al. 1991). Small intestinal ILFs are generated in T- and B cell- deficient mice (RAG-2- -, m- -, TCRp- -, IL-7Ra- -, nu nu ' ), indicating that they develop independently of mature lymphocytes (Hamada et al. 2002). They are absent in neonatal intestines but can be identified 1 or 4 weeks after birth in BALB c or C57BL 6 mice, respectively (Hamada et al. 2002). The question of whether ILFs are secondary lymphoid organs or inducible lymphoid structures that are assembling de novo at sites of chronic Ag stimulation was investigated in germ-free mice (Hamada et al. 2002 Lorenz et al. 2003). Whereas Hamada and colleagues reported the presence of ILFs in germ-free BALB c mice, Lorenz et al. could not find mature ILFs in germ-free C57BL 6 animals (Hamada et al. 2002...

Modifiability of phase 3 of synaptogenesis

Using a more drastic intervention, we found that an early bilateral enucleation (Bourgeois and Rakic, 1996) does not alter the final mean densities of synapses reached at the end of rapid phase 3 and maintained during the phase 4 plateau in the striate cortex of blind monkeys. Our study also indicates that a few weeks after birth the proportions of synaptic contacts situated on dendritic spines (75 ) and shafts (25 ) were similar in all cortical layers of normal and enucleated animals. Four months after birth, the localization on dendritic spines or shafts in the thalamorecipient granular layers fails to mature properly in the absence of normal functional input from the periphery (figure 2.2C). These proportions, which normally become reversed during infancy in sublayers IVAB and IVC, were not reversed in the enucleates. The proportions of symmetric (20 ) versus asymmetric (80 ) synapses located on dendritic spines were within the normal range of variability in both groups of animals....

Effects of environment on diverse phases of synaptogenesis

Very early after birth, when the main aspects of synap-toarchitectony are still being laid down. The patterns of ocular dominance columns are already adult-like in the primary visual cortex of newborn macaques (Horton and Hocking, 1996). Complex receptive field properties, such as face recognition, of inferotemporal neurons are already adult-like, as early as investigators were able to test, i.e., only a few weeks after birth in macaques (Rodman, 1994). The possibility of a cortical circuitry prewired even for highly integrated functions has been invoked (Rodman, 1994). A cardinal cognitive function thought to be subserved by the dorsolateral prefrontal association cortex i.e., performance on Piaget's A not B task see this volume, Stiles (chapter 27), Diamond (chapter 29), Luciana (chapter 41) is present long before the end of the rapid phase 3 of synaptogenesis a few weeks after birth (Bourgeois, Goldman-Rakic, and Rakic, 1994 Diamond and Goldman-Rakic, 1989 Goldman-Rakic, Bourgeois,...

Ontogeny and development

Placental mammals constitute the largest group of mammals. In these species, which includes, cats, dogs, horses, bats, rats and humans, fertilized ova migrate to the uterus where they implant and fuse with the lining of the uterus called en-dometrium, which then leads to the creation of a placenta, a highly vascular membrane that acts as the exchange barrier between embryo(s) and mother. Young develop inside the female tract to varying degrees, but even the most altricial of placental mammals (polar bears Ursus maritimus, for example) still are more developed at birth than marsupials. Internal development can be extremely advanced and lead to birth of young that are able to stand and run almost immediately after birth. Wildebeests, elephants and guinea pigs all have precocial young (offspring born fully developed) in this category.

Dihydrochelirubine 12monooxygenase

Species in which activity has been found in liver microsomes include bandicoot, beef, bettong, kangaroo, man, monkey, mouse, pig, possum, quokka, rat, shrew, tree shrew, rainbow trout, Boophilus, Cunninghamella and Nephila A1218, A1795, A1997, A2420, A3460, B145, D532, E60, J639 . In mammalia the reaction requires three factors for maximal activity cytochrome P450 or P448, a reductase and a lipid component A627, A735 . Cumene hydroperoxide can act as the oxidant A335 . The activity of aniline-4-hydroxylase is not detectable in rat before birth. After birth, activity increases 30-fold to a maximum at weaning, and then declines until at six months it has decreased by 90 per cent A71 . At birth, the activity is five times greater in female than in male rats, with higher activity at 10 than at five weeks age. The development pattern only follows the activity of P450 in broad outline A736 .

General rules of myelination

Myelination of fiber systems mediating sensory input to the thalamus and cerebral cortex precedes myelination of those fiber systems carrying output relating to movement, and these latter fibers myelinate before the association fibers. Thus, the fiber systems mediating vestibular and acoustic input myelinate early and rapidly before birth, the optic radiation and the pre- and postcentral cortical thalamic projections myelinate rapidly during the first year after birth, and these sensory systems anticipate the myelination of the pyramidal systems. Postnatally, the visual and auditory systems tend to have shorter myelination intervals than do pyramidal systems (Kinney et al., 1994 Yakovlev and Lecours, 1967).

Antiretroviral transmission prophylaxis Combination prophylaxis

Ilf the viral load is 10,000 copies ml, combination prophylaxis should be introduced temporarily from 32 + 0 weeks gestation until immediately after birth (Table 4). In the case of high-risk pregnancies (e.g. multigravidity), the prophylaxis is begun at 29 + 0 weeks of gestation.

Diagnosis of HIV infection 18 months of age

The detection of anti-HIV antibodies does not prove an infection in infants. High titers of anti-HIV IgG are transferred transplacentally from mother to child. Maternal antibodies can be detected in children up to the age of 18 months. Therefore a direct method of detecting HIV is necessary. Identification by HIV DNA PCR is highly sensitive and specific. Detection of HIV can be achieved within the first 48 hours after birth in 38 of infected children, and within the first 2 weeks in 93 of children (Dunn 1995). Once a positive HIV PCR is found, a second independent blood sample should soon be taken for repeat PCR analysis. As diverse subtypes of HIV exist, it is advised to test paired samples from mother and infant by HIV DNA PCR. If the mothers virus is not amplified by the primer set used, then another set or another test can be used to avoid a false negative result in the infant. Cord blood is not useful for the diagnosis because maternal cells may be present and may cause a false...

Sequences of CNS myelination

Myelin sheaths appear in the motor root fibers of the spinal nerves at the end of the fourth fetal month, while the sensory fibers begin to myelinate at the end of the fifth month. The motor nerve roots reach their adult pattern of myelination at about term while the sensory nerve rootlets continue to myelinate for several months after birth. Among the cranial nerves, the roots of the eighth pair are the first to show myelinated fibers. At the end of the fifth fetal month, the roots of both divisions of the eighth nerve are myelinated. The oculomotor nerves (III, IV, VI) and the motor division of the trigeminal nerve myelinate next, at about the same time. As in the spinal roots, the cranial motor roots seem to myelinate at a faster pace than the sensory roots. The cycle of myelination of the cranial nerve roots appears to be completed early in the first postnatal year. lamic nuclei. Projections from the specific nuclei of the basal complex (or relay nuclei) myelinate earlier and...

Development of Intestinal Motility

Enteric nerve cells continue to differentiate throughout the first couple of years of life, which means that the infant's nervous system is plastic and developing 37 . There is clear evidence that the development of the ENS continues after birth. In rats, NO synthase-express-ing neurons are already present at birth but increase in number and location during the first 3 weeks of postnatal life 32 . Normal ganglion cell distribution is present at 24 weeks of gestation in humans. These ganglia continue to mature on into childhood. Previous studies on human bowel specimens have revealed that the density of NADPH-diaphorase-positive ganglion cells decreases in the submucous plexus of the human distal colon and the myenteric plexus of human small bowel, colon and rectum 38, 39 .

Regulation of synaptogenesis and control of synaptic maintenance and elimination

The major wave of synaptogenesis in the mammalian brain starts shortly after birth, and lasts for several weeks in rodents and for a much longer period in humans. This wave of massive (as hundreds of billions of synapses have to occur within a relatively short time span) synaptogenesis precisely follows the massive generation of mature astrocytes, which happens during the perinatal period. This sequence of events is not coincidental as indeed astrocytes assist synapse appearance.

Molecular Basis Of Wand Sl Phenotypes

Numerous different W and Sl mutant mice have been studied, and many of the underlying mutations have now been characterized at the molecular level (6). W, the first dominant white spotting mutant described (in the early 1900s) (2), is now known to represent a null mutation affecting c-kit mRNA splicing such that the c-kit polypeptide lacks a transmembrane domain, is not expressed at the cell surface, and lacks kinase activity (4,6). Homozygous animals are severely affected with respect to hematopoiesis, melanogenesis, and gametogenesis and die within a week after birth (1,2). Heterozygotes have some white spotting and coat color dilution but otherwise are relatively normal, and fertile. Therefore the W locus is semidominant. The W (W-viable) mutation represents a Thr660 Met change in the first kinase homology region and confers reduced kinase activity (4,6). Homozygous (WW) animals are affected almost as severely as W W animals, and most die within 3 wk after birth (1,2)....

Neuronal cell formation in the hippocampal formation

Entorhinal cortex are close to what has been observed in adults (Arnold and Trojanowski, 1996a Humphrey, 1967). The only exception to this general pattern concerns the granule cell layer of the dentate gyrus, which first appears during the 13-14th gestational weeks and continues to grow after birth (Humphrey, 1967 Seress, 1992). However, formation of cell layers includes migration of neurons from the place of final cell division. Therefore, in humans, there are no direct data about the exact time of final cell multiplication in the hip-pocampal formadon. zone and move toward the developing dentate gyrus (figure 4.2C). There are labeled cells in all layers of the subicular complex and entorhinal cortex (figure 4.3A,B see color plate 2). Often, the type of labeled cells, based on the morphology of cell nuclei, is unclear but in several cases, glial and endothelial cells are positively identified among the labeled elements (figure 4.3A). While there are no multiplying cells in the...

Avian Models For Reproductive And Neuroendocrine Aging

In captivity under hospitable conditions, some birds (e.g., quail, budgies) have postreproductive life spans of one-third or more of the total life span (Woodard and Aplanalp, 1971 Holmes et al., 2001). Zebra finch hens exhibit significant declines in egg production after several years (Holmes, unpublished data). Female birds and mammals both produce the vast majority of their primary oocytes, or developing eggs, before or shortly after birth (Tokarz, 1978 Guraya, 1989). This fundamental reproductive trait sets birds and mammals apart from most female fishes, amphibians and reptiles, in which

SCFcKit and Lymphopoiesis

A particular class of adult mouse T cells, the CD8-TCR-y5 IELs found in the intestine, seem to be dependent on SCF c-kit in adult mice. These cells mature and undergo recombinational TCR gene rearrangements independently of the thymus are juxtaposed with intestinal epithelial cells in vivo and are thought to contribute to host firstline immune protection against bacterial and viral infection in the intestinal mucosa. TCR-y5 IEL populations become greatly depleted in W W and Sl Sld mice, both in the small intestine and in the large intestine, in an age-dependent fashion that starts approx 6 wk after birth (47,101). In parallel, the TCR-aP IEL population proliferates extensively and undergoes alterations with respect to CD4 CD8 subset ratios, in the small intestine of W W mice (47,101). Thus IEL homeostasis is disrupted, particularly in the

Transmission dynamics

Their description will require knowledge of a number of parameters annual human birthrate in area of study duration of presence of maternal antibodies after birth age-related susceptibility and prevalence of specific antibodies, specified by G and P type age-related incidence of rotavirus infections transmission effectiveness reduction of susceptibility in non-primary infections and significance of animal reservoirs (Desselberger & Estes 2000). On the other hand, modern techniques of phylogenetic analysis of cognate sequences of an appropriate sample will allow characterization of some of the factors determining the spread of rotaviruses (Page & Holmes 1998, E. Holmes, personal communication). Much more work will have to be done to be able to establish an accurate model of the epidemiology and transmission dynamics of rotaviruses.

Treatment of Menkes Disease

Menkes disease patients have been treated by daily injections of copper salts or complexes, such as copper histidine (59), but this treatment has not produced successful results in many patients (14). In responding patients, Cu-therapy prolongs survival and results in clinical improvement, but treatment must be commenced as soon as possible after birth, before significant brain damage has occurred (4,60,61). Even with early treatment, however, not all patients respond to therapy and Kaler has suggested that Mutations of the X-linked mottled locus (Mo) in mice result in varying degrees of copper deficiency and a diverse range of phenotypes. The mottled locus contains the gene Atp7a, the murine ortholog of ATP7A (63,64). There are at least 21 known mutant alleles of the gene, and the mutant phenotypes can be divided into 4 broad groups prenatal lethal, postnatal lethal, viable with mild generalized effects, and mild with pronounced connective tissue defects (65). All except the prenatal...

Animal Models of Wilsons Disease and ICC

There are two proven rodent models of WD, the Long-Evans Cinnamon (LEC) rat and the toxic milk (tx) mouse. The LEC rat accumulates high levels of hepatic copper in the first few months after birth (78) and this excess copper is the likely the cause of early-onset hepatitis. A deletion of the 3' portion of ATP7B has been reported thus demonstrating the LEC rat is a true model of WD (79). Recent experiments have used this rat model to study the possibility of gene correction in WD (80).

Development of principal pyramidal and granule cells and nonprincipal GABAergic neurons of the primate hippocampus

Granule cells, hilar mossy cells, and CA3 pyramidal cells of monkeys are in an advanced stage of development at birth (Seress and Ribak, 1995a,b). Most granule cells have a complete dendritic arbor, although both spine density and the number of synapses in the molecular layer increase after birth (Seress, Baumgartner, and Ribak, 1995). Mossy cells and CA3 pyramidal cells display thorny excrescences, and terminals of mossy fibers (axons of granule cells) establish multiple synapses with those excrescences (Seress and Ribak, 1995a,b). These features indicate that in monkeys developmental events are mainly prenatal, but the chronological sequence of synaptic development is similar to what occurs in the rat. At present we have no data about the development of CA1 pyramidal cells in monkeys. Our preliminary data indicate a change in spine density and myelin formation up to the postnatal seventh month. In conclusion, the monkey hippocampal formation displays a fast and dynamic development...

Structure and Expression of ATP7A and ATP7B Genes

The Menkes gene is expressed in many tissues, although it is not an abundant mRNA Northern blots have detected the message in kidney, lung, heart, brain, testis, gut mucosa, placenta, skeletal muscle, fibroblasts, lymphoblasts, and mammary gland carcinoma cells (91-93,102,103). Very low levels of mRNA were found in mature liver, but in developing liver, the levels are much higher (104), comparable to the kidney, but decline soon after birth (102). High expression was detected in the choroid plexus of the brain. This observation and other evidence for expression of ATP7A in cells of the blood-brain barrier place this protein in position to regulate the entry of copper into the brain, consistent with the severe copper deficiency in the brain of Menkes patients (105). A putative promoter region of the gene has been identified and a possible disease causing mutation was found (106), but no detailed studies on the regulation of the promoter have appeared. There is no evidence that the...

Conclusion and functional implications

Week to the third postnatal month, when cell formation decreases to a minimum but cell migration continues and the first thorny spines appear on the dendrites of hilar mossy cells (2) from the third month to the first year, when cell migration ceases and the first adult-like large thorny excrescences appear on mossy and CA3 pyramidal cells, suggesting the beginning of a period of excessive synapse formation (3) from the first year to the third year, when the first mature-looking mossy cells appear (4) from the third year to the fifth year of life, when most neurons are adult-like both in the hilus and in Ammon's horn. Moreover, it is highly possible that synapse formation continues in the hippocampal formation after the fifth year and results in volumetric and sexual differences (Caviness et al., 1996). However, given currently available morphological methods, these later events cannot be studied. In addition, the number of newly formed granule cells is small after birth therefore, it...

[2 Phenotype Changes of Fut8 Knockout Mouse Core Fucosylation Is Crucial for the Function of Growth Factor Receptors

Semilethality and growth retardation in Fut8 ' mice. (A) Survival ratio of Fut8 ' (- -, striped bar), Fut8+ (+ -, gray bar) mice after birth. (B) A 16-day-old Fut8 ' pup (- -) with a Fut8+ + litter mate (+ +). Fig. 2. Semilethality and growth retardation in Fut8 ' mice. (A) Survival ratio of Fut8 ' (- -, striped bar), Fut8+ (+ -, gray bar) mice after birth. (B) A 16-day-old Fut8 ' pup (- -) with a Fut8+ + litter mate (+ +).

Project Title Inflammatory Response To Fetal Cardiac Surgery

Summary This research endeavor is aimed at understanding the effects of cardiac bypass on the fetus, with the hope that this knowledge will contribute to the development of safe corrective surgery for congenital heart disease in the human fetus. The advantages of early surgical intervention are obvious in defects that would require a much more challenging repair after birth. Prenatal repair would prevent the subsequent development of complex lesions during the fetal period. However, a detailed understanding of the effect of cardiac surgery and extracorporeal circulation on the fetus is required. The focus of this project is to identity the inflammatory mediators responsible for the fetal and placental pathophysiologic response to cardiac bypass using a fetal primate model. The role of cytokines, eicosanoids, and autocoids as candidate mediators of fetal and placental dysfunction will be examined. The effectiveness of attenuating this response with pharmacological antagonists of these...

Myelination of corticolimbic pathways

A broadly accepted marker for the functional maturation of the central nervous system is the formation of myelin sheaths, the insulating covering that surrounds axon shafts. It has long been known that various neural pathways myelinate at different stages of pre- and postnatal development and, for humans, this process has long been thought to continue well after birth, particularly in the prefrontal cortex (Flechsig, 1920 Yakovlev and Lecours, 1967). There is a general tendency, however, for more cephalad structures to myelinate later than those found at more caudal levels of the neuraxis, and for subcortical pathways to myelinate before cortical associational paths (Yakovlev and Lecours, 1967 see

Maternal Investment and Fetal Priming Within an Evolutionary Framework

To appreciate the implications of these types of evolutionary trends for pediatric health, one can look to the progressive changes in how antibody is transferred across the placenta from mother to the infant. Most mammalian species with altricial young provide maternal antibody primarily in breast milk postnatally. However, the higher primates including humans largely transfer immunoglobulin G (IgG) prenatally via the placenta before birth (Coe et al, 1994). This important immune process confers passive protection against bacteria and viruses encountered previously by the mother, enabling the infant to evade disease and to not have to produce substantial amounts of its own antibody for several months after birth. The immunoglobulin found in human milk is predominantly of the IgA class and functions instead to coat the mucosal surfaces of the baby's oral cavity and gut, very distinct from the prenatal bolus of IgG conveying a memory of prior pathogens encountered previously during the...

Developmental changes in specific neurotransmitter systems

Glutamate The amino acid glutamate and the closely related compound aspartate are generally considered to be the transmitters employed by pyramidal neurons projecting to both cortical and subcortical locations (Streit, 1984). The dme course for the maturation of various glutamatergic pathways is probably different. For example, the corticocortical projections originating in the visual cortex of rat brain attain adult levels of glutamate before their corticostriatal counterparts projecting to the caudate nucleus (Johnston, 1988). Interestingly, two days after birth, the level of the glutamate reuptake mechanism is 30 of the levels that are eventually seen at P15. In the visual cortex and in the lateral geniculate nucleus, the reuptake mechanism attains adult levels by P15 and P20, respecdvely (Kvale, Fosse, and Fonnum, 1983). High-affinity glutamate receptors also continue to change postnatally. Between P10 and P15, glutamate receptor binding activity increases by 30 and is 10 times...

The Link Between Birth Weight and Later Health

Analyses of neonatal appearance and fetal growth restriction following a period of under-nutrition or placental insufficiency during pregnancy heralded what has become known today as the 'thrifty phenotype.' That is, when confronted with limited resources during pregnancy, the developing fetus re-programs its growth rate and metabolism in a manner that will facilitate adaptation to further nutrient shortages after birth. Assuming that the prenatal prophecy is correct, such a shift toward a slower growth rate could be advantageous for the baby presenting with a thrifty phenotype. Perhaps enabling it to survive in an adverse world by maximizing the uptake and efficient use of limited nutritional resources. While most clinical attention has been focused on premature and SGA babies, there is a complementary literature indicating that excessive fetal growth can present a different set of problems. With large-for-gestational age babies (LGA), there is a significant increase in obstetrical...

Challenges to Fetal Wellbeing Maternal Stress

With many long-lasting ramifications after birth (Weinstock, 1997). The experimental manipulations used to evoke stress range from immobilization or arousing sensory stimuli in rodent models to stressful husbandry conditions in farm animals and social aggression in primates. Even when gestation length and infant birth weight are not affected, many alterations in the infant's behavioral and physiological functioning have been described (Coe et al, 2007). The offspring from stressed pregnancies often appear to be more behaviorally and emotionally reactive. Thus, when challenged, they continue to manifest larger behavioral and hormonal responses to stressful events. In rats and mice, the secretion of hypothalamic-pituitary-adrenal hormones is typically greater, and increased HPA activity often persists into adulthood (Koehl et al, 1999). Basal levels of adrenal hormones are more typically reported to be normal in primates, but there may be alterations in the diurnal hormone rhythm or an...

Timing of postnatal transmission through breastfeeding

HIV can be transmitted through breast milk at any point during lactation, and thus the rate of infection in breastfed infants increases with duration of breastfeeding. The persistence of maternal antibodies and the presence of a window period during which infection is undetectable by current technology make it difficult to determine whether an infant has been infected during delivery (intrapartum) or - through breastfeeding - immediately after birth. There is too little information to estimate the exact association between duration of breastfeeding and risk of transmission. There is strong evidence, however, that the longer the duration of breastfeeding the greater the risk of transmission - in other words, the risk is cumulative (Miotti et al., 1999 Leroy et al., 1998 Read et al., 2003 Leroy et al., 2002 The Petra Study Team, 2002).

Oxytocin and Vasopressin Information from Animal Models

Ejaculation in males, and formation of long-term pair bonds in those species when monogamy is typical (for reviews, see Carter, 1998 Insel and Young, 2001). During and after pregnancy, oxytocin functions to advance labor and uterine contractions and is involved in initiation of most maternal behaviors including breast feeding, nest building, licking, and warm contact with offspring. Oxytocin is involved in many basic non-reproductive social behaviors as well, including the simple act of socially recognizing a familiar individual (Young, 2002). Oxytocin knockout mice, lacking the gene to produce oxytocin, are less able to recognize a formerly familiar con-specific despite having no deficits in underlying learning or sensory functions. This lack of social recognition disappears if oxytocin is administered to the animal's medial amygdala, while the behavioral deficit can be mimicked in normal mice by administering an oxytocin antagonist to the same region (Ferguson et al, 2000, 2001).

Biological Correlates of Gender

Although genes, chromosomes, hormones, neural structure, and other biological factors contribute to the determination of sex differences before and after birth, environmental factors such as differential cultural reinforcement of sex-appropriate behavior, the imitation of gender-role models, and other psychosocial variables are at least as important (Wittig & Petersen, 1978). As with all human behavior, explanations of gender differences must take into account both the biology of the individual and the environment in which he or she has to function.

Mutations of the a globin genes causing a thalassemia

Gene deletion, since both still have two functioning a genes. Compound heterozygotes with only one a gene (- -a) show more severe red cell abnormalities, including the presence of HbH, and a clinical course that varies from quite mild to fairly severe anaemia. Homozygotes for the double gene deletion (- -) are severely anemic in utero, developing hydrops fetalis and usually dying shortly before or immediately after birth.

Studies in nonprimate female mammals

Another example is a study in which male rats were castrated shortly after birth. Some of the males were given estradiol on postnatal day 5 and some others were given oil. When these animals were treated with estradiol + progesterone in adulthood, it turned out that those given oil neonatally responded with lordosis to a male's mount more frequently than those given estradiol (Feder and Whalen, 1965). As we already know, this kind of study gave rise to the notion of an organizing effect of steroids early in life and an activational effect in adult individuals. There is a huge literature on this subject, which I will not discuss. Any textbook of behavioral endocrinology will analyze the issue at length. I simply conclude that the rodent data show that neonatal endocrine manipulations can alter the likelihood of presentation of specific sexual behaviors, so that neonatal gonadal hormones increase the probability of mounting in both sexes, while the lack of such hormones increases the...

Molecular Biology Of Pheromone Reception

In mice, pheromones are detected by two anatomically distinct olfactory systems the main olfactory system and the vomeronasal (or accessory olfactory) system. The olfactory neurons express a repertoire of olfactory receptors (ORs), which is responsible for detecting volatile odorants and pheromones. The vomeronasal sensory epithelium in the VNO can be divided into apical and basal layers, which express V1R- and V2R-type receptors, respectively (Berghard and Buck, 1996 Dulac and Axel, 1995 Herrada and Dulac, 1997 Matsunami and Buck, 1997 Ryba and Tirindelli, 1997 Tirindelli et al., 1998) (Fig. 6.1). V1Rs and V2Rs begin to be expressed after birth (Dulac and Axel, 1995), whereas ORs

Studies in male nonprimate mammals

Turning to males, the situation is somewhat clearer. This is probably because we have more data on males than on females, as is so often the case. If a male rat is castrated shortly after birth, on postnatal day 0 to be exact, and treated with estra-diol + progesterone when adult, he will not only display lordosis, ear wiggling and hop-darting with the same frequency as a female, bur he will also approach a sexually active male more than a receptive female. When these males received a testosterone implant in adulthood, they changed their behavior and approached a sexually receptive female more than a male (Matuszczyk et al., 1988). This fascinating result suggests that male rats are similar to females in the way that adult hormonal environment determines the preferred sex, while early hormone exposure or lack of such is of minor importance. Similar results were obtained in a study by Meyerson et al. (1979). Their males, castrated shortly after birth, also approached a male more than a...

Developmental anomalies

As part of a major congenital abnormality of the lower abdominal wall musculature the bladder may open directly onto an incompletely formed abdominal wall so-called ectopia vesicae. Previously the bladder was excised and the ureters diverted into the rectum (uretero-sigmoidostomy). With modern surgical reconstructive techniques it is now possible to close the bladder and repair the abdominal wall a few days after birth.

Endocrine events during puberty and their possible importance for sexual preferences

Sexual differentiation has for a long time been considered as an event taking place before, around or shortly after birth. During the last few years, it has become apparent that this notion is overly simplified. Something must happen in the brain sometime between the late postnatal period and the end of puberty. For example, sexual behavior cannot be activated to adult levels in prebubertal male hamsters, rats or ferrets even when treated with large doses of androgens. Similarly, absence of gonadal hormones during puberty leads to a reduced responsiveness to these hormones when adult. Male hamsters deprived of androgens during puberty mount, intromit and ejaculate less in a test for copulatory behavior than hamsters exposed to physiological concentrations of these hormones. Not only do pubertal androgens enhance male-typical sexual behaviors in response to androgen treatment in adulthood, but they also reduce the expression of female-typical behaviors. Again, male hamsters not exposed...

SNRPN Small Nucleoribonucleoprotein Polypeptide N

Like other genes in the PWS area of humans, the mouse Snrpn is expressed from the paternal allele, as shown by RNAse protection assays (Leff et al., 1992), and mice having maternal UPD7 for the relevant area do not express the Snrpn gene and die shortly after birth (Cattanach et al., 1992). Additional mouse loci encode related splicing factors to Snrpn such as SmB the latter, however, is no substitute for Snrpn (Glenn et al., 1997). Studies of the Snrpn knock-out mouse showed, however, that the neuronal-specific alternative splicing of the RNAs encoding several different classes of protein proceeds normally (Huntriss et al., 1994).

Generation of Mucosal IgA in Organized Follicular Structures

The GALT, which is the main site for generation of mucosal immune responses, is generally divided into two compartments inductive sites, represented by organized follicular structures, and effector sites, represented by diffuse tissue of the intestinal LP (Brandtzaeg et al. 1999 Fagarasan and Honjo 2003). The major inductive sites in the small intestine are PP and solitary follicles that are scattered throughout the intestine, called isolated lymphoid follicles (ILF) (Hamada et al. 2002), which develop before and after birth, respectively. Their organization requires multiple interactions between inducer cells of hematopoietic origin and organizer mesenchymal cells (Nishikawa et al. 2003). Among the key events absolutely necessary for PP and ILF formation is the expression of LTa102 on CD3-CD4+IL-7R+ inducer cells on stimulation through IL-7R and its interaction with LT0R+ organizer cells (Honda et al. 2001 Lorenz et al. 2003 McDonald et al. 2005 Yoshida et al. 2002). Sev

Recruitment of IgM B Cells to the Gut LP

Indeed, LTpR- - mice and aly aly mice, which have impaired signaling through LTpR because of a point mutation in the downstream signaling molecule nuclear factor-KB-inducing kinase (NIK) (Shinkura et al. 1999), are completely devoid of IgM+ B cells and IgA plasma cells in the gut LP (Fagarasan et al. 2000 Kang et al. 2002). Reconstitution of aly aly or LTpR- -with BM cells fails to restore the number of B cells and IgA plasma cells in the gut, unless coinjected with NIK-sufficient gut stromal cells or transplanted with a segment of normal small intestine (Kang et al. 2002 Suzuki et al. 2005). These facts, together with the observation that administration of LTpR antagonists after birth causes a marked decrease in the number of LP B cells and plasma cells (Newberry et al. 2002), demonstrate the essential role of permanent signaling through LTpR NIK on gut stromal cells for the B cell recruitment to gut. Although the impaired LTa-LTpR interaction is suggested to affect the local...

Trident leafnosed bat

Available evidence suggests that females are pregnant in the spring and give birth to a single young in early summer. Gestation time is estimated at 9-10 weeks, and the young nurse for 40 days after birth, after which they become independent. The time of mating is unknown. Most likely polygynous.

Parnells moustached bat

Females bear a single young annually after a gestation period of about 50 days. The young are naked and helpless at birth. The timing of reproduction varies across the species' range, with births usually peaking around the start of the rainy season. For example, if mating occurs in autumn, the sperm is typically stored by females throughout hibernation, sometimes up to seven months, in the uterus. Within a few days of leaving their winter shelter, females ovulate one egg, and sperm are released. Fertilization and implantation then take place shortly afterwards. Typically, females of a population form a maternity colony at a site different than the hibernation site where breeding occurred. Gestation usually lasts from 40 to 50 days and results in a single offspring, usually in the late spring. Birth is a rather uneasy process hanging inverted, mothers grab the newborn as it emerges from the birth canal and the newborn in turn grabs the abdominal fur of the mother with its hind feet,...

Development of Lewis antigens

Lewis antigens start to appear on red cells soon after birth 740 . Lea develops first red cells of infants with an Le gene generally become Le(a+) during the first few months of life. In white people, at 3 months of age 80 of infants are Le(a+), this number dropping to the adult level of 20 by 2 years 741-743 . During this period the red cell phenotype Le(a+b+) is not uncommon 743,744 . By 6 years of age the proportion of Le(b+) reaches the adult level 743 .

The Jennerian Approach

Moreover, an important study in 1979 demonstrated the feasibility of this strategy colostrum-deprived gnotobiotic calves infected in utero experimentally by injection of bovine rotavirus NCDV into the amniotic sac 2-14 weeks before delivery were protected against challenge with a heterologous human rotavirus shortly after birth 38 . Furthermore, it was found later that most of the calves developed serum neutralizing antibodies to heterotypic G1, G2 or G3 specificity 39 . This study established the rationale for adopting the Jennerian approach for a rotavirus vaccine. Later, in 1983, this concept was confirmed in colostrum-deprived piglets with the RIT 4237 bovine rotavirus candidate vaccine 40 .

Future of Transgenic Mouse Approaches Need for Inducible Expression

Many eukaryotic promoters are under natural inducible control, providing a simple means for controlling the extent and duration of expression. For example, in the absence of heavy metals, the MT promoter has low activity. Treatment with cadmium or zinc, however, increases promoter activity several fold. The effectiveness of this induction scheme was demonstrated in transgenic mice harboring a mutated sheep MT promoter linked to an ovine GH-cod-ing sequence. When maintained on water supplemented with zinc, these mice secreted excessive levels of GH and displayed a giant phenotype (Shanahan et al., 1989). Mice overexpressing GH have also been made with a transgene that utilizes the PEPCK promoter (McGrane et al., 1988). Transcription of the chimeric gene occurred after birth in the kidney, liver, and adipose tissue. This promoter is regulated by composition of the diet a diet high in carbohydrates reduces expression whereas a diet high in protein and low in carbohydrate stimulates...

Postmortem Organ Weights

Current recommendations for evaluation of all stillbirths and infants dying within 24 hours after birth (neonatal deaths) include gross and microscopic autopsy of the fetus and the placenta, postmortem photography and radiography, analysis of bacterial cultures, karyotyping of the fetal tissues, and saving tissue for DNA studies when indicated

Animal Models Of Macular Degeneration

In 1986, a single cynomolgus monkey (Macaca fascicu-laris) with heavy drusen was found in the Tsukuba Primate Research Center. After 19 years of mating experiments, that single pedigree has grown to having 57 affected and 182 unaffected monkeys. Macular changes are observed as early as two years after birth, with basal laminar deposits first appearing in the macular region and progressing toward the peripheral retina throughout the lifetime (see Figure 68.4). In all the cases examined no abnormalities were found in the optic disc, retinal blood vessels, or choroidal vasculatures. The affected monkeys share phenotypic similarities with the early stages of ARMD, such as drusen and accumulation of lipofuscin. The immunohistochemical and proteome analysis of drusen in these monkeys share significant similarity with composition of age-related macular degeneration monkeys and also with previously reported human drusen composition. The meaning of this observation is that early onset monkeys...

Animal Models Of Poag

Membrane trafficking and cellular morphogenesis. OPTN is induced by TNF-a and binds to an inhibitor of TNF-a and the adenovirus E3-14.7 kDa protein. To determine the effects of human glaucoma mutations in a transgenic mouse system, mice over-expressing wild type OPTN, OPTN carrying the glaucoma associated mutation E50K, and OPTN with exon5 deleted were constructed. Although wild-type OPTN do not show any abnormalities and the exon 5 deleted construction was found to be lethal prenatally, mice transgenic for the E50K mutant OPTN show steep optic nerve cupping with rearrangement of supporting tissue and blood vessels 18 weeks after birth (see Figure 68.6). The RGC and astrocyte loss observed is similar to the end phase changes seen in human glaucoma patients. Understanding the mechanism underlying normal tension glaucoma in these transgenic mice will enhance our understanding of each step leading to optic nerve cupping and how to prevent it. Based on the success of the mouse model, use...

Congenital dislocation and developmental dysplasia of hip

Previously this condition was known as congenital dislocation of the hip (CDH). However the correct term is developmental dysplasia of hip (DDH) because in many cases the condition is not present at birth but rather develops after birth. Secondly in a majority of cases there is no frank dislocation but a dysplasia (poorly developed acetabulum) leading to instability of the hip joint.

Development Of Intestinal Microbiota In Dogs And Cats

Intestinal colonization is a gradual process starting immediately after birth. In newborn puppies and kittens the alimentary canal is sterile but is quickly inhabited by bacteria from birth canal and environment. The dam usually licks the newborn thoroughly thus transferring its own indigenous bacteria to her offspring. Within 24 hours the numbers of bacteria in various parts of the gastrointestinal tract of a newborn puppy are similar to those of an adult dog (2).

Clinical Manifestations

HHT is characterized by skin, mucosal membrane, and visceral telangiectasias, recurrent epistaxis, and visceral hemorrhages. The recurrent epistaxis is usually the first and most common sign of the disease. The lesions seen on physical exam are small, dark red telangiectases, with ill-defined borders and stellate appearance, occurring most commonly on the face, lips, tongue, palms, and fingers (Fig. 6). The telangiectasias seen on the skin and mucous membranes actually represent small AVMs, which explains their propensity to bleed. Visceral AVMs are found mostly in the lungs, central nervous system (CNS), upper gastrointestinal tract, and liver. The number and location of telangiectasias and AVMs vary widely between individuals and within the same family. The external, visible signs (telangiectasias and frequent nose bleeds) often do not manifest until the second or third decade of life. Internal AVMs in the brain, spinal cord, and lungs are thought to be largely congenital lesions...

Monitoring Hiv Rna in Children

Quantitative HIV RNA assays can be obtained to assess the numbers of copies of RNA and, indirectly, the virion level or viral burden. A balance is reached in HIV-infected individuals between 6 and 12 months following acute infections, such that there is a steady state of on-going viral production and immune elimination replacement.4041 Plasma HIV-1 RNA levels increase rapidly after birth, peak at 1 -2 months of age (median values at 1 and 2 months, 318,000 and 256,000 copies ml, respectively), and then slowly decline to a median of 34,000 copies ml at 24 months.7 Adult levels are reached by age 6 years. Extreme levels of HIV RNA (300,000 copies ml) correlate with disease progression and death within the first 12 months of life. Levels during the first year of life are associated with a 54 reduction in progression for each logw reduction in HlV RNA level. Baseline as well as changes in HIV RNA copy number and CD4 lymphocyte percentage over time independently predict mortality in...

Manipulation of the Gastrointestinal Microbiota by Application of Probiotic Microorganisms

Development of the rumen microbiota in calves and lambs can be supported by microbial preparations mainly at the start of dry feeding. Effective use of microbial preparations in the young depends also on the level of knowledge of the so-called environmental factors in the rumen which determine the age at which a given microorganism may colonize the rumen and enable the development of cellulolytic microbiota (71). The specificity of using probiotics in calves, lambs and goatlings consists in the possibility of influencing the formation of the ruminal ecosystem application of selected strains of rumen microorganisms lays the foundation of a future population showing a high fermentation activity. Colonization with selected cultures of living microorganisms should enable an earlier and more stable onset of the ruminal type of digestion. Controlled action on the rumen microbiota in the young during milk nutrition is mainly related to the effect upon development of the microbiota adhering...

Gnotobiotic Ruminants in Studies into the Microbiota of the Gastrointestinal Tract

Gnotobiotic ruminants can be used to observe the development of the rumen ecosystem as well as to study the relations between rumen and its microbiota. The rumen microbiota directly affects the development of the rumen epithelium and the level of intermediary metabolism by the action of rumen fermentation and its final metabolites. Fonty and coworkers (90), using meroxenic lambs demonstrated that the functions of the rumen and the stability of the ecosystem depended on the complexity and diversity of the microbiota. In the light of the present knowledge it is not possible to precisely determine the composition of the minimum microbiota enabling rumen development and function. Fonty and coworkers (91) also studied the role of rumen microbiota in the development of the rumen ecosystem and functional development of the rumen at an early age. Their results suggest that the rumen microbiota of the very young lamb plays an essential role in the establishment of the rumen ecosystem and in...

Dairy products and probiotics in childhood disease

The age of two years (46 versus 23 ) (Kalliomaki et al., 2001b). However, there was no decrease in antigen-specific IgE by L. rhamnosus GG administration. The authors performed a four-year follow up of the study group. Sixty-seven percent of the initially randomised children were re-examined. In the probiotic supplemented population there was a significantly decreased prevalence of atopic eczema compared with the non-treated group (14 of 53 versus 25 of 54 children) (Kalliomaki et al., 2003). No difference was found upon skin prick test reactivity. Another long-term follow up study was able to shown that intentional colonisation of the intestine with E. coli 083 (K24LH31) after birth decreased the incidence of allergies after 10 and 20 years after colonisation (Lodinova-Zadnikova et al., 2003).

Pulmonary Circulation and Ventilation Perfusion Ratios

Tery to the aorta through the ductus arteriosus (described in chapter 13). After birth, the foramen ovale and ductus arteriosus close, and the vascular resistance of the pulmonary circulation falls sharply. This fall in vascular resistance at birth is due to (1) opening of the vessels as a result of the subatmospheric in-trapulmonary pressure and physical stretching of the lungs during inspiration and (2) dilation of the pulmonary arterioles in response to increased alveolar Po2.

Latent Viral Genome Load Defining the Risk of Recurrence

The mouse model has revealed that infection history matters (Reddehase et al. 1994). Mice infected as neonates within 24 h after birth showed delayed clearance of acute, productive infection in organs and prolonged persistence in the salivary glands, whereas fully immunocompetent mice infected as adults rapidly controlled acute infection in all organs and showed a shortened persistence in the salivary glands. Months later, during replicative latency, this different history of primary infection was reflected by high or low load of viral genomes, respectively, in organs including lungs, spleen, heart, kidney, adrenal glands, and salivary glands. Importantly, viral DNA load is a predictor of the risk of virus recurrence after hematoablative total-body y-irradiation, with high or low load predicting high or low incidence of recurrence, respectively. Recurrence turned out to be a focal and stochastic event occurring independently in different latently infected organs, thus leading to all...

A Ghrhr and Its Ligand

GHRHR expression changes during fetal development and throughout the life. In rat pituitary, GHRHR first appears on embryonic day 19 (E19)38-40 and reaches a peak during E20 with no subsequent increase.41 Receptor expression declines after birth and surges again during puberty. A final decrease in GHRHR expression is seen with aging.42,43

EEG and the Effects of Hormone Treatment

Golgeli and colleagues (2004) examined the effects of growth hormone (GH) replacement therapy on cognitive function in women with Sheehan's syndrome. Sheehan's syndrome is also known as postpartum hypopituitarism, a pituitary hormone deficiency as a result of life-threatening blood loss during or after childbirth. At baseline, amplitude and latencies of auditory oddball ERPs of patients showed longer latencies than those of controls. After 6 months of hormone replacement therapy, patients showed decreased P300 latencies compared to pre-treatment levels. The authors conclude that Sheehan's syndrome is associated with cognitive impairment as demonstrated by prolonged P300 latencies and the improvement with GH replacement. The conclusions of this study could have been strengthened if the paper had reported EEG measures in the control group as well, after a 6-month period.

Electrical Activity of the Heart and the Electrocardiogram

The lungs of a fetus are collapsed, and blood is routed away from the pulmonary circulation by an opening in the interatrial septum called the foramen ovale (fig. 13.15) and by a connection between the pulmonary trunk and aorta called the ductus arteriosus (fig. 13.16). These shunts normally close after birth, but when they remain open (are patent), murmurs can result. Since blood usually goes from left to right through these shunts, the left ventricle still pumps blood that is high in oxygen. When other defects are present that increase the pressure in the right pump (as in the tetralogy of Fallot), however, a significant amount of oxygen-depleted blood from the right side of the heart may enter the left side. The mixture of oxygen-poor blood from the right side with oxygen-rich blood in the left side of the heart lowers the oxygen concentration of the blood ejected into the systemic circulation. Since blood low in oxygen imparts a bluish tinge to the skin, the baby may be born...

Physical characteristics

The body coloration can consist of a solid shade in some, the belly is lighter, while in others, the pelage is patterned. In some species, the patterned coloration is for crypsis and camouflage, such as light stripes against a darker ground that help break the body outline. Such a pelage pattern is seen in the aptly named zebra duiker (Cephalophus zebra) and the sitatunga (Tragelaphus spekii). In others such as gemsbok (Oryx gazella), contrasting colors and body markings are used for intraspecific displays. The sexes often are differently colored, with males usually having the darker pelage. Frequently within species, there are also age-specific colorations. For example, for the first few weeks or months after birth, the pelage color of young is quite different from that of adults, such as in the orange-brown coat of young bison (Bison bison), which contrasts to the dark burnt-sienna brown of the adults. In species such as blackbuck (Antilope...

African brushtailed porcupine

Birth, eyes are open, teeth are already present, and hair (but not spines) covers the body. Young are born small, only 3 of mother's body weight. Weight at birth averages 5 oz (150 g) with a range of 3.5-6.3 oz (100-175 g, then increases to 18 oz (500 g) after one month, 2 lb (1 kg) after three months, 3 lb (1.5 kg) after five months, and 22 lb (10 kg) after 11 months. Both parents spend much time and effort raising offspring. Mothers nurse nearly constantly for first two months after birth teats are located laterally on the chest. Sexual maturity is reached at about two years. Documented to live up to 23 years of age.

Expression Of Scf And cKit mRNAs

Expression of SCF and c-kit mRNAs in tissues of the mouse during embryogenesis and after birth has been thoroughly studied by in situ hybridization (38-41). A number of important results emerged from these studies 4. For many of the tissues discussed, contiguous expression of SCF and c-kit mRNAs continued to be apparent by in situ hybridization after birth and into adulthood. Such tissues include hematopoietic tissues (bone marrow and spleen), the skin and hair follicles, the gonads, the gastrointestinal tract, and the CNS.

Methods of Age Determination in Bats

After birth, bats grow quickly, achieving almost full adult size prior to fledging (Barclay, 1994 Jones and MacLarnon, 2001). During this time, long bones grow linearly and many researchers use forearm length measured with calipers to determine age of growing juveniles. In fact, this method provides very accurate estimates of age (Anthony, 1988). Its usefulness, however, is restricted to the first 2 to 6 weeks after birth, depending on species (Brunet-Rossinni and Wilkinson, in review). During this growth phase, the cartilaginous epiphyseal growth plates of the phalanges in the wing first expand to generate the phalangeal growth necessary for wing development and then become increasingly calcified. This process results in a linear increase and subsequent linear decrease in total length of the cartilaginous region between the boney diaphysis of a metacarpal and the boney diaphysis of the proximal phalanx (a.k.a. total gap). Epiphyseal growth plates are easily visualized by...

Relationships Between The Intestinal Immune System And Intestinal Microbiota

The intestinal microbiota also interacts with the other lines of defense, innate and acquired immunities. These effects can be of particular importance during the early postnatal life that is a period of high risk for intestinal disorders due to enteric pathogens and or food hypersensitivities. During the neonatal period, mammalian species exhibit some degree of reduced immunocompetence that could be attributed to a functional immaturity in cells involved in immune intestinal responses. It could be also attributed to the lack of bacterial stimulation given by the intestinal microbiota which is absent during the fetal life. After birth, a well-balanced bacterial colonization will educate the IIS in a good manner allowing immunoregulatory mechanisms governing IIS functions to operate rapidly.

Gestation and neonate type

An inverse relationship between the average number of offspring produced at birth (litter size) and the gestation period is only to be expected. For a given uterus volume, there is clearly a trade-off between the number of developing offspring and the extent to which they can develop prior to birth. One corollary of this is that, for any given adult body size, al-tricial offspring must grow more after birth than precocial offspring.

Cardiac Maturation

Although the embryonic heart is fully formed and functional by the 11th week of pregnancy, the fetal and neonatal heart continue to grow and mature rapidly, with many clinically relevant changes taking place after birth. During fetal development, or from the time after the embryo is completely formed in the first trimester of pregnancy until birth, the heart grows primarily by the process of cell division (28-31). Within a few weeks after birth, the predominant mechanism of cardiac growth is cell hypertrophy in other words, existing cardiac cells become larger rather than increasing significantly in number (28-30). In addition, the maturing myocardial cells undergo changes in the expression of their contractile proteins, which may be responsible for some of the maturational differences in cardiovascular function. Changes in expression of contractile proteins that may be important in humans include a gradual increase in the expression of myosin light chain 2 (MLC 2) in the ventricle...

Height Velocity

Growth velocity is the rate of growth over a period of time (Figs. 4.23-4.25). It is most rapid immediately after birth and then, between the ages of 2 and 12 years in boys, or 2 and 10 years in girls, growth velocity slowly continuously decelerates. During adolescence, it increases again. The adolescence peak for girls is a approximately 12 years and boys, at approximately 14 years of age. It is useful to compare growth velocity with the normal yearly intervals If a girl was 99 cm at 3 years 6 months and measured 106 cm at 4 years 4 months, she has grown 5 cm in 10 months (or presumably 6 cm per year). This rate is compared to her age at the middle of this time interval (3 years, 11 months) and gives the growth velocity for her at that age. In infancy, shorter time intervals are used to evaluate growth velocity.

Mountain gazelle

Males attend to one or more females and their young generally in groups of 3-8. Estrous occurs every 18 days and lasts 12-24 hours, repeating until the female becomes pregnant. Males and females reproduce with various partners. Females usually give birth to one baby per season (and, on average, 11 in her lifetime). The usual mating season is in early winter (October to November), although mating also occurs in the spring (April to mid-May) and at other times when food is plentiful. The gestation period is about 180 days. Newborns generally weigh about 11-12 of the mother's weight. Mothers give birth away from the herd. The newborn can stand shortly after birth, and spends the first few weeks nursing. They begin to take solid food when they are 3-6 weeks old, but suckling may last up to three months. Males do not contribute to the care of the young. At this time, mother and young will join a maternity herd. Female young will remain with the mother, but male young will leave...

Parous Phenotypes

In the rat, Dao, et al. (6,7) reported that treatment with 3-methylcholanthrene failed to induce mammary cancers in pregnant or post partum lactating Sprague Dawley (SD) rats. Moon (8) reported that SD rats that had undergone a full-term pregnancy, followed by involution oftheir mammary glands, were more resistant to DMBA-induced MC than their age-matched nulliparous controls. He observed that mammary glands of parous rats required twice as much estrogen compared to the glands of nulliparous rats to induce the equivalent amount of growth. Chakravarty (21) found that the splenocytes from parous rats had cytolytic activity against mammary cancer cells weeks after pregnancy, and the effect decreased with time.

Sexual maturity

Sexual maturity in many species occurs when body size reaches adult size. However, there are some notable exceptions male least weasels (Mustela nivalis) often seek maternity dens of females and will copulate the newly born females, as soon as 4 hours after birth. At that time, neonates still have their eyes and ears closed, are pink and hairless. This strategy enables females to have a first litter within weeks of birth (least weasels do not exhibit delayed implantation), and then again before the end of their first year. Another example of early sexual maturity is in musk shrews (Suncus murinus) in which mating and repeated ejaculations from males induce puberty and ovulation in virgin females.


During evolution, GALT develops from primitive lymphoid cell clusters with bothhematopoietic and immune function to organized tissues able to generate highly specific adaptive immune responses. In mice, the cellular interactions between lymphoid tissue inducer cells and mesenchymal organizer cells regulate PP and LN development during ontogeny. The formation of cell clusters triggers a series of signaling events involving adhesion molecules, cytokines, chemokines, and TNF-family member molecules. The activation of integrins via molecular feedback loops appears to be essential for the prolonged cell-to-cell contact between the inducer and the organizer cells. The expression of adhesion molecules and chemokines by organizer cells is induced via LTPR signaling, thus leading to the recruitment and compartmentalization of mature lymphocyte subsets. The inducer cells are the major cell population engaging LTpR on stromal cells via LTap. After birth, the maintenance of organized lymphoid...


Postpartum depression is a relatively common occurrence in women after childbirth. One female who started taking 300 mg of St. John's wort (Jarsin 300) three times daily after meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for major depressive episode 5 months after delivery agreed to have milk samples tested. Hypericin was not detected in the milk samples, but hyperforin was detected at low concentrations, with higher levels in the hind-milk than the foremilk samples. The milk plasma ratio was well below one for both hypericin and hyperforin. Both levels were undetectable in the infant's serum and the baby showed no negative side effects

Milk composition

In order for the secretion of colostral immunoglobins to be effective, the neonatal gut needs to remain permeable to their absorption and minimize any upper-tract digestion of these proteins. The time the mammalian intestine remains permeable to the intact immunoglobins varies between species 24-36 hours after birth in the case of ungulates 16-20 days in mice and rats eight days in mink and 100-200 days in large marsupials. The marsupial's prolonged absorption capabilities relate to the time the young reside in the mother's pouch.


The thymus lies partly in the neck anterior to the trachea and partly in the anterior mediastinum in the chest. The organ has a profuse blood supply and lymphatic drainage. It consists of two to three lobes subdivided in lobules by fibrous trabeculae. Each lobule has a cortex and a medulla containing epithelial cells and thymocytes, which are immature T-cells. The gland starts enlarging during foetal life and reaches its largest size at puberty after which it begins to regress. The main function of the thymus is a bed for T-lymphocyte maturation, which involves commitment of surface receptors to recognition of a specific antigen. Most of T-cell maturation occurs during foetal life and for a short time after birth. Removal of the thymus in the neonatal period therefore results in severe T-cell deficiencies, yet removal of the gland from an adult generally

Wand Sl Phenotypes

Normal embryonic hematopoiesis in the mouse occurs in the yolk sac blood islands during d 7-11 and then in the fetal liver until about d 17. Hematopoietic activity begins in the fetal spleen about d 15 and begins in fetal bone marrow near the end of gestation, continuing throughout life in both tissues. Mature hematopoietic status in the adult animal is reach by about 8-10 wk after birth. In W and Sl mutant animals, erythropoiesis and other aspects of hematopoiesis in the embryonic yolk sac and fetal liver can be impaired. Defects in hematopoiesis after birth are described in detail in Subheading 7.1.


Eruption of the deciduous teeth usually occurs between 6 and 24 months after birth (Fig. 7.89). The permanent teeth develop in a manner similar to that just described. As a permanent tooth grows, the root of the corresponding deciduous tooth is gradually resorbed by osteoclasts. Consequently, when the deciduous tooth is shed, it consists only of the crown and the uppermost portion of the root. The permanent teeth usually begin to erupt during the sixth year and continue to appear until early adulthood. They are often serrated initially and become smooth with time. The chronology of onset of prenatal and postnatal enamel formation is illustrated in Figure 7.90. Details of dental age are provided in Chapter 13.

Whitetailed mouse

Have an unusual method of raising young soon after birth, the young attach themselves to their mother's mammae and remain attached for about three weeks. The female drags them about during this time. They continue to suckle intermittently for another 2-3 weeks. The survival rate of young is high for rodents, as the mother can provide direct protection for her young. Sexual maturity is reached at about five months of age and litters can be produced as often as every 36 days. Mean litter size is 2.9 young. In captivity, they may live as long as six years lifespan in the wild is unknown.

Allergiesan Overview

It is clear that there is a hereditary trait that predisposes to the formation of allergen-specific IgE antibodies and development of allergic disease (27). This genetic predisposition, known as atopy, affects arguably as many as 30-50 of the world population (2,25,27). Although the immunopathological mechanisms in established allergic diseases are well characterized, it is poorly understood how and why atopy leads or does not lead to allergic sensitization and why only some sensitized individuals develop symptomatic allergic disease (30). Intriguingly, the immune responses to common environmental allergens are initially dominated by Th2 cells in all newborn infants but these responses are not suppressed in atopic infants during the first year of life (31,32). This is thought to be due to defects associated with atopy, for example, impaired production of IFN-g, which compromise the normal maturation of Th2 antagonistic Th1 responses. The major driving force for the Th1 maturation is...

Prion Diseases

Copper ions might induce an a-helical motif in the N-terminus of the protein to act as a template for the formation of the a-helices in the rest of the protein. Indeed, Cu(II) binding to the repeat segment of PrPC can induce formation of the a-helical structure on the C-terminal side of the peptide chain (96). The lack of copper binding might play a role in the pathogenesis because infectivity of prions is based on the P-sheet conformation of the protein, rather than on the a-helical structure and the acquisition of partial resistance to digestion with proteinase K (91,97). The importance of the N-terminal region of PrP was underlined when PrP transgenes were found to restore the susceptibility to the disease (98). PrP amino-proximal deletions of residues 32-121 or 32-134 caused severe ataxia and neuronal death in knockout mice shortly after birth, whereas the wild-type PrP gene abolished this effect (98). In contrast to the mammalian homologs, the chicken prion protein N-terminal...

Mantled guereza

Births are typically single and occur year-round. Young infants are commonly passed around among females other than the mother, and also carried by them, even quite soon after birth. This species has been little studied in captivity, so basic reproductive features such as the gestation period remain unknown.

Baxbcl2 Proteins

A differential and unique expression of apoptosis-regulating Bcl-2 family proteins has been demonstrated in the rat brain during the course of development and aging. Bcl-2 is expressed highly during embryonic development but is downregulated after birth (as early as one week) (Min et al., 2003). During naturally occurring cell death (NOCD) in the rat cerebral cortex, neurons expressing Bcl-2 may determine whether a neuron dies or survives, as over-expression of Bcl-2 in transgenic mice protects neurons from NOCD (Martinou et al., 1994). Low levels of Bcl-2 protein are still present in the adult

Caspase Proteins

The expression of each caspase is differentially regulated during the development and aging of the brain. One of the most studied was caspase-3, a typical pro-apoptotic executioner protease. A profound downregulation of caspase-3 transcription has been reported between postnatal day 1 (P1) and 12 (P12) (de Bilbao et al., 1999). Developmental regulation of pro-caspase-3 translation has also been reported with high and low or even undetectable levels in the newborn and adult brain, respectively (Krajewska et al., 1997 Ni et al., 1997 Hu et al., 2000). Caspase-3 expression displays an inverse correlation with cytochrome c, as demonstrated in the rat brain (Blomgren et al., 2001 Zhu et al., 2003). It has also recently been demonstrated that procaspase-3 in the neonatal P7 rat cortex exists as a complex of molecular weight of 170 kDa (Kurosu et al., 2004). Caspase-7, -8, and -10 are also highly expressed during embryonic and early postnatal development, but are downregulated after birth...

CNS myelin

Lipids Cholesterol is a major component of myelin, together with phospholipids and glycolipids, in ratios ranging from 4 3 2 to 4 4 2. Myelin phospholipids are not unusual, but myelin lipids are rich in glycosphingolipids, in particular galactocerebrosides (GalC) and their sulphated derivatives, sulphatides, which are used immunohistochemically to identify myelinating oligodendrocytes. The functions of GalC have been studied in mice with an inactive gene for the enzyme that catalyzes the final step in the synthesis of GalC (UDP-galactose ceramide galactosyl transferase (CGT)). These mice have no detectable levels of GalC or sulphatides, and display a pronounced tremor starting at about two weeks (the age after birth when active myelination is at its peak in rodents). The abnormalities of internodal myelin spacing and the complete absence of transverse bands at the paranodal axo-glial junctions indicate an essential role for galactolipids in axon-glial interactions. The role of...