CMyc Deregulation in Cancer

C-Myc overexpression is associated with neoplasms of different tissues, including breast (11,12), neuroblastoma (13), cervical carcinoma (14), malignant melanoma (15), prostate cancer (16), osteogenic sarcoma (17), and lymphoid cancer (6, 18, 19) (reviewed in 20). Thus, Myc protein overexpression is an important player in cellular transformation (21-25). Figure 1. c-Myc-dependent locus-specific and karyotypic instability in neoplasia. Figure 1. c-Myc-dependent locus-specific and karyotypic...

Cell Molecular Biology Breast Cancer

Bi-directional Regulation of Human Progesterone Receptors and the Mitogen Activated Protein Kinase Pathway in Breast Cancer Cell Models Emily Faivre, Ming Qiu, and Carol A. 381 Abnormal Properties of Mutants in the Hinge Region of ErV Implications in Breast Cancer Carlos Mart nez-Campa, Pedro Zuazua, Juana Mar a Garc a-Pedrero, Pedro Casado, Pedro S nchez Lazo, and Sof a Ramos 391 The Effects of Eicosapentaenoic Acid Upon Proliferation and 17 -Dehydrogenase Activity in MCF-7 Breast Carcinoma...

Proliferative Inflammatory Atrophy PIA

GSTP1 is typically expressed at high levels in PIA lesions (7). These prostate lesions are composed of proliferating, atrophic-appearing, prostate epithelial cells that are often juxtaposed to activated inflammatory cells (7). The epithelial cells present are distinct in several ways from the atrophic epithelial cells seen after androgen deprivation or anti-androgen treatment. First, PIA lesions are focal, not diffuse. PIA cells are often proliferating quite actively, rather than lying...

References

Wang YZ, Wong YC (1998) Sex hormone induced prostatic carcinogenesis in the Noble rat the role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of PCA Prostate 35 165-177. 2. Wong YC, Xie W, Tsao SW (2000) Structural changes and alteration in expression of TGF-betal and its receptors in prostatic intraepithelial neoplasia (PIN) in the ventral prostate of Noble rats. Prostate 45 289-298. 3. Tam NNC, Chung SSM, Lee DTW, et al (2000) Aberrant...

Introduction

PCA is the most diagnosed cancer in men, and is the second leading cause of male cancer deaths in the USA (1). PCA is multifocal, and the cancerous gland contains multiple independent tumors, demonstrating disease heterogeneity (2). A unique PCA characteristic is its initial dependence on As for growth. As a result, standard strategies for PCA treatment rely on blockade of A action by 1. Decreasing circulating A levels via chemical or physical castration or 2. Treatment with As (i.e., DHT) that...

Results

A total of 76 metaphase spreads (9-12 MGT), obtained from 8 individual E-induced primary MGT from 8 female ACI rats were subjected to G-banding karyotype analysis. A representative karyotype from a primary MGT is shown in Figure 1. Note trisomies in chromosomes 6, 8,10,13, and 19 and tetrasomies in 7,11, and 15. The chromosomal alterations seen in 3, 4, and 20 were random. The total gain frequency of chromosomes 7 and 20 were 100 (8 8) for 19, 87.5 (7 8) and for 11 and 13, 62.5 (5 8). Only...

Materials and Methods

Serum and tissue samples of 30 animals presented at Veterinary Teaching Hospital of Veterinary School (Madrid), with at least one mammary tumor, were prospectively collected. The animals were physically and radiographically examined. Surgical excision was the treatment ofchoice except in IMC cases, in which surgery is not the first choice recommended. Samples were obtained by tru-cut biopsy or necropsy. For this study, samples were divided in two adjacent fragments, one was...