Aggressiveness

Can centrosome amplification be utilized as an indicator oftumor progression, the potential to develop aggressive tumor phenotypes, and to serve as a prognostic indicator of clinical outcome? Centrosome amplification is not only characteristic of aneuploid tumors in general, but also is more pronounced in advanced stage malignancies, in recurrent tumors, and in cell lines that show more aggressive malignant phenotypes in xenograph animal models (10, 11, 16, 29). These observations suggest that centrosome amplification might be useful in monitoring tumor progression and phenotypic diversity in cancer. In association with other established prognostic factors, centrosome amplification may be helpful in predicting outcomes and survival of patients with cancer. And finally, because the centrosome may serve as a structural context for the action of key cell cycle regulators, it may also represent a critical target for therapeutic intervention.

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