Concluding Remarks

Cyclin E deregulation has been associated with an array of human malignancies. Evidence suggests that the most critical parameter may be deregulation relative to the cell cycle, which can occur if the normal pathway of cyclin E turnover is inactivated. The resulting expression of cyclin E at inappropriate times of the cell cycle can then interfere with efficient progression through both S phase and M phase. Although not yet proven, we propose that these cyclin E-mediated cell cycle perturbations ultimately result in chromosome instability.

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