This review emphasized the role of individual varieties of cellular and tissue changes in the human breast and their relation to BC risk. Further, any identifiable associations with hormonal relationships are emphasized. Therefore, much ofthis evidence from tissue based studies and epidemiologic studies of subsequent BC risk, as well as concurrent associations of and other hormone substances in various lesions. There are very few follow up studies, therefore, most of these relationships must remain as implications derived from concurrent association in breast tissue (40) associated with developed carcinomas (41). The cancer implications and associations of hormone expression in premalignant lesions are few but promising because of the obvious importance of the lines of evidence for each element. However, the integration ofhormone expression with varied lesions in the prospective evaluation of BC development and progression awaits further experience.

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