We have shown that prostate cancer (PCA) cells can exist in four stages of progression in culture media or in experimental animals based on their androgen (A) dependency or sensitivity. This is in contrast with the common characterization of prostate tumors as occurring in two forms, simply based on whether the tumors are A-dependent or A-independent. Recognition of four different forms of PCA strongly suggests that the current design of hormonal therapy by anti-androgenic agents requires revision; otherwise the practice may be very harmful to patients. In this chapter, we summarize our effort in understanding the four forms of PCA cells and show that their growth or proliferation can be suppressed or eradicated in culture or in athymic mice by selectively utilizing anti-androgen, A, or green tea (-)epigallocatechin-3-gallate (EGCG).

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