Physiologic Effects Of Hyperbaric Oxygen On Ischemiareperfusion Phenomenon

Rachmaninov's Third Piano Concerto in Hyperbaric Physiology Sven Van Poucke1, Philippe Jorens2 and Luc Beaucourt1

1Unit of Hyperbaric Medicine, Department of Emergency Medicine, 2Department of Intensive Care Medicine, University Hospital Antwerp, Belgium

Abstract: Reperfusion injury is a complex but clinically well-defined entity although its complete mechanism is not entirely elucidated yet. The re-oxygenation phase is characterized by vasoconstriction, platelet and polymorphonuclear leukocytes activation, and release of mediators and the production of free radicals. The goals of the available therapeutic approaches are to oppose directly the consequences of re-oxygenation following the ischemic phase. Clinical and research evidence demonstrated that hyperbaric oxygen could be effective to reduce or stop ischemia-reperfusion related injury. Although many unanswered questions remain and the effects of hyperbaric oxygen seem paradoxical at first glance, the supportive literature is growing

Keywords: hyperbaric oxygen; ischemia-reperfusion; free radicals; hypoxia; no-reflow; oxygen paradox

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