Tcell Prolymphocytic Leukemia Tpll And Tcell Chronic Lymphocytic Leukemia Tcll

Most of the T cell non-Hodgkin lymphomas are relatively rare compared to their B cell counterparts in the Western world, and for this reason, have been less exhaustively studied. Among these uncommon disorders are the entities referred to variously as T-PLL and T-CLL. T-PLL is a rare peripheral T-cell leukemia lymphoma with the following characteristics an absolute lymphocytosis typically with concomitant hepatosplenomegaly, anemia, and thrombocytopenia. The incidence of lymphadenopathy and...

Reed Sternberg Cell

Popcorn Cells

The classic Reed-Sternberg (RS) cell or a variant RS cell (L& H cell, lacunar cell) must be present for a diagnosis of HL to be made. Not only must this cell be present, but it must be found in a cellular milieu of one of the five histologic subtypes of HL, because cells morphologically indistinguishable from RS cells may also be found in benign lymphoid proliferations as well as in non-Hodgkin's lymphomas. There are three types of RS cells 1) classic, 2) lacunar cell, and 3) lymphocytic and...

Info

WBC leukocyte count, RBC erythrocyte count, HGB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width, PLT platelet count, MPV mean platelet volume WBC leukocyte count, RBC erythrocyte count, HGB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width, PLT platelet...

References

Multiple myeloma evolving genetic events and host interactions. Nat Rev Cancer 2002 2 175-187. 2. Fonseca R, Bailey RJ, Ahmann GJ, Rajkumar SV, Hoyer JD, Lust JA, Kyle RA, Gertz MA, Greipp PR, Dewald GW. Genomic abnormalities in monoclonal gammopathy of undetermined significance. Blood 2002 1000 1417-1424. 3. Zandecki M, Lai JL, Genevieve F, Bernardi F, Volle-Remy H, Blanchet O, Francois M Cosson A, Bauters F, Facon T. Several cytogenetics subclones may be identified...

Angiogenesis In Myeloproliferative Disorders

Increased blood flow in myeloproliferative disorders was noted over 30 years ago.57 Subsequent studies have documented increased bone marrow vascularity or blood flow in myelofibrosis,58-65 chronic myelogenous leukemia (CML),22, 58, 63, 66, 67 essential thrombocythemia (64) and polycythemia vera.64 The mediators of angiogenesis in myeloproliferative disorders appear to be VEGF and bFGF. In myelofibrosis, megakaryocytic cells have been shown to express increased levels of bFGF,65, 68, 69 and...

Angiogenesis In Myelodysplastic Syndrome Mds And Acute Myeloid Leukemia

Numerous groups have documented increased vascularity in bone marrow biopsies of patients with AML22-29 and MDS,23, 29-31 as compared to normal control bone marrow biopsies. In our study26 we specifically looked at angiogenesis in acute promyelocytic leukemia (APL), which is a subtype of AML. We showed that bone marrow angiogenesis is increased in APL, and is decreased after treatment with all-trans retinoic acid. A similar decrease in angiogenesis, after therapy, has been seen in other...