In an age where diet and environmental related oxidation and infectious diseases are on the rise, the role of dietary phenolic phytochemicals in preventive management of diseases is becoming important. Strategies to improve functional phytochemicals that addresses the problem of consistency have to be developed. Within this framework we have developed strategies for isolating clonal dietary herbs of single seed genetic origin with a specific profile of phenolic phytochemicals and also stress elicitation based enhancement of phenolic phytochemicals during legume seed sprouting. The rationale for development of these techniques for phenolic phytochemical enhancement for functional food design is based on harnessing the potential of proline linked pentose-phosphate pathway (PLPPP) as the critical control point (CCP) in clonal shoots of single seed genetic origin such as herbs from the family Lamiaceae and seed sprouts in self-pollinating species such as various legumes. This strategy can be extended to develop foods with better phenolic phytochemical profile and functionality. Further it can be extended to develop functional foods and supplements with consistent ingredient profiles targeted against a disease condition. This concept is now being extended to specifically isolate antioxidants for diverse disease conditions, antimicrobials against bacterial pathogens, phytochemicals for diabetes management, angiotensin converting enzyme inhibitors for hypertension management, l-DOPA for Parkinson's management, dietary cyclooxygenase (COX-2 inhibitors) for inflammatory diseases and isoflavones for women's health.
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