Methods In Enzymology

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Volume I. Preparation and Assay of Enzymes Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume II. Preparation and Assay of Enzymes Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume III. Preparation and Assay of Substrates Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume IV. Special Techniques for the Enzymologist Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume V. Preparation and Assay of Enzymes Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume VI. Preparation and Assay of Enzymes (Continued) Preparation and Assay of Substrates Special Techniques

Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume VII. Cumulative Subject Index

Edited by Sidney P. Colowick and Nathan O. Kaplan

Volume VIII. Complex Carbohydrates

Edited by Elizabeth F. Neufeld and Victor Ginsburg

Volume IX. Carbohydrate Metabolism Edited by Willis A. Wood

Volume X. Oxidation and Phosphorylation

Edited by Ronald W. Estabrook and Maynard E. Pullman

Volume XI. Enzyme Structure Edited by C. H. W. Hirs

Volume XII. Nucleic Acids (Parts A and B) Edited by Lawrence Grossman and Kivie Moldave

Volume XIII. Citric Acid Cycle Edited by J. M. Lowenstein

Volume XIV. Lipids Edited by J. M. Lowenstein

Volume XV. Steroids and Terpenoids Edited by Raymond B. Clayton

Volume XVI. Fast Reactions Edited by Kenneth Kustin

Volume XVII. Metabolism of Amino Acids and Amines (Parts A and B)

Edited by Herbert Tabor and Celia White Tabor

Volume XVIII. Vitamins and Coenzymes (Parts A, B, and C) Edited by Donald B. McCormick and Lemuel D. Wright

Volume XIX. Proteolytic Enzymes

Edited by Gertrude E. Perlmann and Laszlo Lorand

Volume XX. Nucleic Acids and Protein Synthesis (Part C) Edited by Kivie Moldave and Lawrence Grossman

Volume XXI. Nucleic Acids (Part D)

Edited by Lawrence Grossman and Kivie Moldave

Volume XXII. Enzyme Purification and Related Techniques Edited by William B. Jakoby

Volume XXIII. Photosynthesis (Part A) Edited by Anthony San Pietro

Volume XXIV. Photosynthesis and Nitrogen Fixation (Part B) Edited by Anthony San Pietro

Volume XXV. Enzyme Structure (Part B) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume XXVI. Enzyme Structure (Part C) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume XXVII. Enzyme Structure (Part D) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume XXVIII. Complex Carbohydrates (Part B) Edited by Victor Ginsburg

Volume XXIX. Nucleic Acids and Protein Synthesis (Part E) Edited by Lawrence Grossman and Kivie Moldave

Volume XXX. Nucleic Acids and Protein Synthesis (Part F) Edited by Kivie Moldave and Lawrence Grossman

Volume XXXI. Biomembranes (Part A) Edited by Sidney Fleischer and Lester Packer

Volume XXXII. Biomembranes (Part B) Edited by Sidney Fleischer and Lester Packer

Volume XXXIII. Cumulative Subject Index Volumes I-XXX Edited by Martha G. Dennis and Edward A. Dennis

Volume XXXIV. Affinity Techniques (Enzyme Purification: Part B) Edited by William B. Jakoby and Meir Wilchek

Volume XXXV. Lipids (Part B) Edited by John M. Lowenstein

Volume XXXVI. Hormone Action (Part A: Steroid Hormones) Edited by Bert W. O'Malley and Joel G. Hardman

Volume XXXVII. Hormone Action (Part B: Peptide Hormones) Edited by Bert W. O'Malley and Joel G. Hardman

Volume XXXVIII. Hormone Action (Part C: Cyclic Nucleotides) Edited by Joel G. Hardman and Bert W. O'Malley

Volume XXXIX. Hormone Action (Part D: Isolated Cells, Tissues, and Organ Systems)

Edited by Joel G. Hardman and Bert W. O'Malley

Volume XL. Hormone Action (Part E: Nuclear Structure and Function) Edited by Bert W. O'Malley and Joel G. Hardman

Volume XLI. Carbohydrate Metabolism (Part B) Edited by W. A. Wood

Volume XLII. Carbohydrate Metabolism (Part C) Edited by W. A. Wood

Volume XLIII. Antibiotics Edited by John H. Hash

Volume XLIV. Immobilized Enzymes Edited by Klaus Mosbach

Volume XLV. Proteolytic Enzymes (Part B) Edited by Laszlo Lorand

Volume XLVI. Affinity Labeling

Edited by William B. Jakoby and Meir Wilchek

Volume XLVII. Enzyme Structure (Part E) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume XLVIII. Enzyme Structure (Part F) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume XLIX. Enzyme Structure (Part G) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume L. Complex Carbohydrates (Part C) Edited by Victor Ginsburg

Volume LI. Purine and Pyrimidine Nucleotide Metabolism Edited by Patricia A. Hoffee and Mary Ellen Jones

Volume LII. Biomembranes (Part C: Biological Oxidations) Edited by Sidney Fleischer and Lester Packer

Volume LIII. Biomembranes (Part D: Biological Oxidations) Edited by Sidney Fleischer and Lester Packer

Volume LIV. Biomembranes (Part E: Biological Oxidations) Edited by Sidney Fleischer and Lester Packer

Volume LV. Biomembranes (Part F: Bioenergetics) Edited by Sidney Fleischer and Lester Packer

Volume LVI. Biomembranes (Part G: Bioenergetics) Edited by Sidney Fleischer and Lester Packer

Volume LVII. Bioluminescence and Chemiluminescence Edited by Marlene A. DeLuca

Volume LVIII. Cell Culture

Edited by William B. Jakoby and Ira Pastan

Volume LIX. Nucleic Acids and Protein Synthesis (Part G) Edited by Kivie Moldave and Lawrence Grossman

Volume LX. Nucleic Acids and Protein Synthesis (Part H) Edited by Kivie Moldave and Lawrence Grossman

Volume 61. Enzyme Structure (Part H) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume 62. Vitamins and Coenzymes (Part D)

Edited by Donald B. McCormick and Lemuel D. Wright

Volume 63. Enzyme Kinetics and Mechanism (Part A: Initial Rate and

Inhibitor Methods)

Edited by Daniel L. Purich

Volume 64. Enzyme Kinetics and Mechanism

(Part B: Isotopic Probes and Complex Enzyme Systems)

Edited by Daniel L. Purich

Volume 65. Nucleic Acids (Part I)

Edited by Lawrence Grossman and Kivie Moldave

Volume 66. Vitamins and Coenzymes (Part E)

Edited by Donald B. McCormick and Lemuel D. Wright

Volume 67. Vitamins and Coenzymes (Part F)

Edited by Donald B. McCormick and Lemuel D. Wright

Volume 68. Recombinant DNA Edited by Ray Wu

Volume 69. Photosynthesis and Nitrogen Fixation (Part C) Edited by Anthony San Pietro

Volume 70. Immunochemical Techniques (Part A) Edited by Helen Van Vunakis and John J. Langone

Volume 71. Lipids (Part C) Edited by John M. Lowenstein

Volume 72. Lipids (Part D) Edited by John M. Lowenstein

Volume 73. Immunochemical Techniques (Part B) Edited by John J. Langone and Helen Van Vunakis

Volume 74. Immunochemical Techniques (Part C) Edited by John J. Langone and Helen Van Vunakis

Volume 75. Cumulative Subject Index Volumes XXXI, XXXII, XXXIV-LX Edited by Edward A. Dennis and Martha G. Dennis

Volume 76. Hemoglobins

Edited by Eraldo Antonini, Luigi Rossi-Bernardi, and Emilia Chiancone

Volume 77. Detoxication and Drug Metabolism Edited by William B. Jakoby

Volume 78. Interferons (Part A) Edited by Sidney Pestka

Volume 79. Interferons (Part B) Edited by Sidney Pestka

Volume 80. Proteolytic Enzymes (Part C) Edited by Laszlo Lorand

Volume 81. Biomembranes (Part H: Visual Pigments and Purple Membranes, I) Edited by Lester Packer

Volume 82. Structural and Contractile Proteins (Part A: Extracellular Matrix) Edited by Leon W. Cunningham and Dixie W. Frederiksen

Volume 83. Complex Carbohydrates (Part D) Edited by Victor Ginsburg

Volume 84. Immunochemical Techniques (Part D: Selected Immunoassays) Edited by John J. Langone and Helen Van Vunakis

Volume 85. Structural and Contractile Proteins (Part B: The Contractile Apparatus and the Cytoskeleton)

Edited by Dixie W. Frederiksen and Leon W. Cunningham

Volume 86. Prostaglandins and Arachidonate Metabolites Edited by William E. M. Lands and William L. Smith

Volume 87. Enzyme Kinetics and Mechanism (Part C: Intermediates, Stereo-chemistry, and Rate Studies) Edited by Daniel L. Purich

Volume 88. Biomembranes (Part I: Visual Pigments and Purple Membranes, II) Edited by Lester Packer

Volume 89. Carbohydrate Metabolism (Part D) Edited by Willis A. Wood

Volume 90. Carbohydrate Metabolism (Part E) Edited by Willis A. Wood

Volume 91. Enzyme Structure (Part I)

Edited by C. H. W. Hirs and Serge N. Timasheff

Volume 92. Immunochemical Techniques (Part E: Monoclonal Antibodies and

General Immunoassay Methods)

Edited by John J. Langone and Helen Van Vunakis

Volume 93. Immunochemical Techniques (Part F: Conventional Antibodies,

Fc Receptors, and Cytotoxicity)

Edited by John J. Langone and Helen Van Vunakis

Volume 94. Polyamines

Edited by Herbert Tabor and Celia White Tabor

Volume 95. Cumulative Subject Index Volumes 61-74, 76-80 Edited by Edward A. Dennis and Martha G. Dennis

Volume 96. Biomembranes [Part J: Membrane Biogenesis: Assembly and Targeting (General Methods; Eukaryotes)] Edited by Sidney Fleischer and Becca Fleischer

Volume 97. Biomembranes [Part K: Membrane Biogenesis: Assembly and Targeting (Prokaryotes, Mitochondria, and Chloroplasts)] Edited by Sidney Fleischer and Becca Fleischer

Volume 98. Biomembranes (Part L: Membrane Biogenesis: Processing and Recycling)

Edited by Sidney Fleischer and Becca Fleischer

Volume 99. Hormone Action (Part F: Protein Kinases) Edited by Jackie D. Corbin and Joel G. Hardman

Volume 100. Recombinant DNA (Part B)

Edited by Ray Wu, Lawrence Grossman, and Kivie Moldave

Volume 101. Recombinant DNA (Part C)

Edited by Ray Wu, Lawrence Grossman, and Kivie Moldave

Volume 102. Hormone Action (Part G: Calmodulin and Calcium-Binding Proteins)

Edited by Anthony R. Means and Bert W. O'Malley

Volume 103. Hormone Action (Part H: Neuroendocrine Peptides) Edited by P. Michael Conn

Volume 104. Enzyme Purification and Related Techniques (Part C) Edited by William B. Jakoby

Volume 105. Oxygen Radicals in Biological Systems Edited by Lester Packer

Volume 106. Posttranslational Modifications (Part A) Edited by Finn Wold and Kivie Moldave

Volume 107. Posttranslational Modifications (Part B) Edited by Finn Wold and Kivie Moldave

Volume 108. Immunochemical Techniques (Part G: Separation and Characterization of Lymphoid Cells)

Edited by Giovanni Di Sabato, John J. Langone, and Helen Van Vunakis

Volume 109. Hormone Action (Part I: Peptide Hormones) Edited by Lutz Birnbaumer and Bert W. O'Malley

Volume 110. Steroids and Isoprenoids (Part A) Edited by John H. Law and Hans C. Rilling

Volume 111. Steroids and Isoprenoids (Part B) Edited by John H. Law and Hans C. Rilling

Volume 112. Drug and Enzyme Targeting (Part A) Edited by Kenneth J. Widder and Ralph Green

Volume 113. Glutamate, Glutamine, Glutathione, and Related Compounds Edited by Alton Meister

Volume 114. Diffraction Methods for Biological Macromolecules (Part A) Edited by Harold W. Wyckoff, C. H. W. Hirs, and Serge N. Timasheff

Volume 115. Diffraction Methods for Biological Macromolecules (Part B) Edited by Harold W. Wyckoff, C. H. W. Hirs, and Serge N. Timasheff

Volume 116. Immunochemical Techniques

(Part H: Effectors and Mediators of Lymphoid Cell Functions)

Edited by Giovanni Di Sabato, John J. Langone, and Helen Van Vunakis

Volume 117. Enzyme Structure (Part J) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume 118. Plant Molecular Biology

Edited by Arthur Weissbach and Herbert Weissbach

Volume 119. Interferons (Part C) Edited by Sidney Pestka

Volume 120. Cumulative Subject Index Volumes 81-94, 96-101

Volume 121. Immunochemical Techniques (Part I: Hybridoma Technology and Monoclonal Antibodies)

Edited by John J. Langone and Helen Van Vunakis

Volume 122. Vitamins and Coenzymes (Part G) Edited by Frank Chytil and Donald B. McCormick

Volume 123. Vitamins and Coenzymes (Part H) Edited by Frank Chytil and Donald B. McCormick

Volume 124. Hormone Action (Part J: Neuroendocrine Peptides) Edited by P. Michael Conn

Volume 125. Biomembranes (Part M: Transport in Bacteria, Mitochondria, and Chloroplasts: General Approaches and Transport Systems) Edited by Sidney Fleischer and Becca Fleischer

Volume 126. Biomembranes (Part N: Transport in Bacteria, Mitochondria, and

Chloroplasts: Protonmotive Force)

Edited by Sidney Fleischer and Becca Fleischer

Volume 127. Biomembranes (Part O: Protons and Water: Structure and Translocation) Edited by Lester Packer

Volume 128. Plasma Lipoproteins (Part A: Preparation, Structure, and Molecular Biology)

Edited by Jere P. Segrest and John J. Albers

Volume 129. Plasma Lipoproteins (Part B: Characterization, Cell Biology, and Metabolism)

Edited by John J. Albers and Jere P. Segrest

Volume 130. Enzyme Structure (Part K) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume 131. Enzyme Structure (Part L) Edited by C. H. W. Hirs and Serge N. Timasheff

Volume 132. Immunochemical Techniques (Part J: Phagocytosis and Cell-Mediated Cytotoxicity)

Edited by Giovanni Di Sabato and Johannes Everse

Volume 133. Bioluminescence and Chemiluminescence (Part B) Edited by Marlene DeLuca and William D. McElroy

Volume 134. Structural and Contractile Proteins (Part C: The Contractile Apparatus and the Cytoskeleton) Edited by Richard B. Vallee

Volume 135. Immobilized Enzymes and Cells (Part B) Edited by Klaus Mosbach

Volume 136. Immobilized Enzymes and Cells (Part C) Edited by Klaus Mosbach

Volume 137. Immobilized Enzymes and Cells (Part D) Edited by Klaus Mosbach

Volume 138. Complex Carbohydrates (Part E) Edited by Victor Ginsburg

Volume 139. Cellular Regulators (Part A: Calcium- and Calmodulin-Binding Proteins)

Edited by Anthony R. Means and P. Michael Conn

Volume 140. Cumulative Subject Index Volumes 102-119,121-134

Volume 141. Cellular Regulators (Part B: Calcium and Lipids) Edited by P. Michael Conn and Anthony R. Means

Volume 142. Metabolism of Aromatic Amino Acids and Amines Edited by Seymour Kaufman

Volume 143. Sulfur and Sulfur Amino Acids Edited by William B. Jakoby and Owen Griffith

Volume 144. Structural and Contractile Proteins (Part D: Extracellular Matrix) Edited by Leon W. Cunningham

Volume 145. Structural and Contractile Proteins (Part E: Extracellular Matrix) Edited by Leon W. Cunningham

Volume 146. Peptide Growth Factors (Part A) Edited by David Barnes and David A. Sirbasku

Volume 147. Peptide Growth Factors (Part B) Edited by David Barnes and David A. Sirbasku

Volume 148. Plant Cell Membranes Edited by Lester Packer and Roland Douce

Volume 149. Drug and Enzyme Targeting (Part B) Edited by Ralph Green and Kenneth J. Widder

Volume 150. Immunochemical Techniques (Part K: In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors) Edited by Giovanni Di Sabato

Volume 151. Molecular Genetics of Mammalian Cells Edited by Michael M. Gottesman

Volume 152. Guide to Molecular Cloning Techniques Edited by Shelby L. Berger and Alan R. Kimmel

Volume 153. Recombinant DNA (Part D) Edited by Ray Wu and Lawrence Grossman

Volume 154. Recombinant DNA (Part E) Edited by Ray Wu and Lawrence Grossman

Volume 155. Recombinant DNA (Part F) Edited by Ray Wu

Volume 156. Biomembranes (Part P: ATP-Driven Pumps and Related

Transport: The Na, K-Pump)

Edited by Sidney Fleischer and Becca Fleischer

Volume 157. Biomembranes (Part Q: ATP-Driven Pumps and Related Transport: Calcium, Proton, and Potassium Pumps) Edited by Sidney Fleischer and Becca Fleischer

Volume 158. Metalloproteins (Part A)

Edited by James F. Riordan and Bert L. Vallee

Volume 159. Initiation and Termination of Cyclic Nucleotide Action Edited by Jackie D. Corbin and Roger A. Johnson

Volume 160. Biomass (Part A: Cellulose and Hemicellulose) Edited by Willis A. Wood and Scott T. Kellogg

Volume 161. Biomass (Part B: Lignin, Pectin, and Chitin) Edited by Willis A. Wood and Scott T. Kellogg

Volume 162. Immunochemical Techniques (Part L: Chemotaxis and Inflammation)

Edited by Giovanni Di Sabato

Volume 163. Immunochemical Techniques (Part M: Chemotaxis and Inflammation)

Edited by Giovanni Di Sabato

Volume 164. Ribosomes

Edited by Harry F. Noller, Jr., and Kivie Moldave

Volume 165. Microbial Toxins: Tools for Enzymology Edited by Sidney Harshman

Volume 166. Branched-Chain Amino Acids Edited by Robert Harris and John R. Sokatch

Volume 167. Cyanobacteria

Edited by Lester Packer and Alexander N. Glazer

Volume 168. Hormone Action (Part K: Neuroendocrine Peptides) Edited by P. Michael Conn

Volume 169. Platelets: Receptors, Adhesion, Secretion (Part A) Edited by Jacek Hawiger

Volume 170. Nucleosomes

Edited by Paul M. Wassarman and Roger D. Kornberg

Volume 171. Biomembranes (Part R: Transport Theory: Cells and Model Membranes)

Edited by Sidney Fleischer and Becca Fleischer

Volume 172. Biomembranes (Part S: Transport: Membrane Isolation and Characterization)

Edited by Sidney Fleischer and Becca Fleischer

Volume 173. Biomembranes [Part T: Cellular and Subcellular Transport:

Eukaryotic (Nonepithelial) Cells]

Edited by Sidney Fleischer and Becca Fleischer

Volume 174. Biomembranes [Part U: Cellular and Subcellular Transport:

Eukaryotic (Nonepithelial) Cells]

Edited by Sidney Fleischer and Becca Fleischer

Volume 175. Cumulative Subject Index Volumes 135-139,141-167

Volume 176. Nuclear Magnetic Resonance (Part A: Spectral Techniques and Dynamics)

Edited by Norman J. Oppenheimer and Thomas L. James

Volume 177. Nuclear Magnetic Resonance (Part B: Structure and Mechanism) Edited by Norman J. Oppenheimer and Thomas L. James

Volume 178. Antibodies, Antigens, and Molecular Mimicry Edited by John J. Langone

Volume 179. Complex Carbohydrates (Part F) Edited by Victor Ginsburg

Volume 180. RNA Processing (Part A: General Methods) Edited by James E. Dahlberg and John N. Abelson

Volume 181. RNA Processing (Part B: Specific Methods) Edited by James E. Dahlberg and John N. Abelson

Volume 182. Guide to Protein Purification Edited by Murray P. Deutscher

Volume 183. Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences Edited by Russell F. Doolittle

Volume 184. Avidin-Biotin Technology Edited by Meir Wilchek and Edward A. Bayer

Volume 185. Gene Expression Technology Edited by David V. Goeddel

Volume 186. Oxygen Radicals in Biological Systems (Part B: Oxygen Radicals and Antioxidants)

Edited by Lester Packer and Alexander N. Glazer

Volume 187. Arachidonate Related Lipid Mediators Edited by Robert C. Murphy and Frank A. Fitzpatrick

Volume 188. Hydrocarbons and Methylotrophy Edited by Mary E. Lidstrom

Volume 189. Retinoids (Part A: Molecular and Metabolic Aspects) Edited by Lester Packer

Volume 190. Retinoids (Part B: Cell Differentiation and clinical Applications) Edited by Lester Packer

Volume 191. Biomembranes (Part V: Cellular and Subcellular Transport: Epithelial cells)

Edited by Sidney Fleischer and Becca Fleischer

Volume 192. Biomembranes (Part W: Cellular and Subcellular Transport: Epithelial cells)

Edited by Sidney Fleischer and Becca Fleischer

Volume 193. Mass Spectrometry Edited by James A. McCloskey

Volume 194. Guide to Yeast Genetics and Molecular Biology Edited by Christine Guthrie and Gerald R. Fink

Volume 195. Adenylyl Cyclase, G Proteins, and Guanylyl Cyclase Edited by Roger A. Johnson and Jackie D. Corbin

Volume 196. Molecular Motors and the Cytoskeleton Edited by Richard B. Vallee

Volume 197. Phospholipases Edited by Edward A. Dennis

Volume 198. Peptide Growth Factors (Part C)

Edited by David Barnes, J. P. Mather, and Gordon H. Sato

Volume 199. Cumulative Subject Index Volumes 168-174,176-194

Volume 200. Protein Phosphorylation (Part A: Protein Kinases: Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression) Edited by Tony Hunter and Bartholomew M. Sefton

Volume 201. Protein Phosphorylation (Part B: Analysis of Protein Phosphorylation, Protein Kinase inhibitors, and Protein Phosphatases) Edited by Tony Hunter and Bartholomew M. Sefton

Volume 202. Molecular Design and Modeling: Concepts and Applications (Part A: Proteins, Peptides, and Enzymes) Edited by John J. Langone

Volume 203. Molecular Design and Modeling:

Concepts and Applications (Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs) Edited by John J. Langone

Volume 204. Bacterial Genetic Systems Edited by Jeffrey H. Miller

Volume 205. Metallobiochemistry (Part B: Metallothionein and Related Molecules)

Edited by James F. Riordan and Bert L. Vallee Volume 206. Cytochrome P450

Edited by Michael R. Waterman and Eric F. Johnson Volume 207. Ion Channels

Edited by Bernardo Rudy and Linda E. Iverson

Volume 208. Protein-DNA Interactions Edited by Robert T. Sauer

Volume 209. Phospholipid Biosynthesis

Edited by Edward A. Dennis and Dennis E. Vance

Volume 210. Numerical Computer Methods Edited by Ludwig Brand and Michael L. Johnson

Volume 211. DNA Structures (Part A: Synthesis and Physical Analysis of DNA)

Edited by David M. J. Lilley and James E. Dahlberg

Volume 212. DNA Structures (Part B: Chemical and Electrophoretic Analysis of DNA)

Edited by David M. J. Lilley and James E. Dahlberg

Volume 213. Carotenoids (Part A: Chemistry, Separation, Quantitation, and Antioxidation) Edited by Lester Packer

Volume 214. Carotenoids (Part B: Metabolism, Genetics, and Biosynthesis) Edited by Lester Packer

Volume 215. Platelets: Receptors, Adhesion, Secretion (Part B) Edited by Jacek J. Hawiger

Volume 216. Recombinant DNA (Part G) Edited by Ray Wu

Volume 217. Recombinant DNA (Part H) Edited by Ray Wu

Volume 218. Recombinant DNA (Part I) Edited by Ray Wu

Volume 219. Reconstitution of Intracellular Transport Edited by James E. Rothman

Volume 220. Membrane Fusion Techniques (Part A) Edited by Nejat DUzgUnes

Volume 221. Membrane Fusion Techniques (Part B) Edited by Nejat DUzgUnes

Volume 222. Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation (Part A: Mammalian Blood Coagulation Factors and inhibitors)

Edited by Laszlo Lorand and Kenneth G. Mann

Volume 223. Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation (Part B: Complement Activation, Fibrinolysis, and Nonmammalian Blood Coagulation Factors) Edited by Laszlo Lorand and Kenneth G. Mann

Volume 224. Molecular Evolution: Producing the Biochemical Data Edited by Elizabeth Anne Zimmer, Thomas J. White, Rebecca L. Cann, and Allan C. Wilson

Volume 225. Guide to Techniques in Mouse Development Edited by Paul M. Wassarman and Melvin L. DePamphilis

Volume 226. Metallobiochemistry (Part C: Spectroscopic and

Physical Methods for Probing Metal Ion Environments in Metalloenzymes and Metalloproteins)

Edited by James F. Riordan and Bert L. Vallee

Volume 227. Metallobiochemistry (Part D: Physical and Spectroscopic Methods for Probing Metal Ion Environments in Metalloproteins) Edited by James F. Riordan and Bert L. Vallee

Volume 228. Aqueous Two-Phase Systems Edited by Harry Walter and Gote Johansson

Volume 229. Cumulative Subject Index Volumes 195-198, 200-227

Volume 230. Guide to Techniques in Glycobiology Edited by William J. Lennarz and Gerald W. Hart

Volume 231. Hemoglobins (Part B: Biochemical and Analytical Methods) Edited by Johannes Everse, Kim D. Vandegriff, and Robert M. Winslow

Volume 232. Hemoglobins (Part C: Biophysical Methods)

Edited by Johannes Everse, Kim D. Vandegriff, and Robert M. Winslow

Volume 233. Oxygen Radicals in Biological Systems (Part C) Edited by Lester Packer

Volume 234. Oxygen Radicals in Biological Systems (Part D) Edited by Lester Packer

Volume 235. Bacterial Pathogenesis (Part A: Identification and Regulation of Virulence Factors)

Edited by Virginia L. Clark and Patrik M. Bavoil

Volume 236. Bacterial Pathogenesis (Part B: Integration of Pathogenic Bacteria with Host Cells)

Edited by Virginia L. Clark and Patrik M. Bavoil

Volume 237. Heterotrimeric G Proteins Edited by Ravi Iyengar

Volume 238. Heterotrimeric G-Protein Effectors Edited by Ravi Iyengar

Volume 239. Nuclear Magnetic Resonance (Part C) Edited by Thomas L. James and Norman J. Oppenheimer

Volume 240. Numerical Computer Methods (Part B) Edited by Michael L. Johnson and Ludwig Brand

Volume 241. Retroviral Proteases

Edited by Lawrence C. Kuo and Jules A. Shafer

Volume 242. Neoglycoconjugates (Part A) Edited by Y. C. Lee and Reiko T. Lee

Volume 243. Inorganic Microbial Sulfur Metabolism Edited by Harry D. Peck, Jr., and Jean LeGall

Volume 244. Proteolytic Enzymes: Serine and Cysteine Peptidases Edited by Alan J. Barrett

Volume 245. Extracellular Matrix Components Edited by E. Ruoslahti and E. Engvall

Volume 246. Biochemical Spectroscopy Edited by Kenneth Sauer

Volume 247. Neoglycoconjugates (Part B: Biomedical Applications) Edited by Y. C. Lee and Reiko T. Lee

Volume 248. Proteolytic Enzymes: Aspartic and Metallo Peptidases Edited by Alan J. Barrett

Volume 249. Enzyme Kinetics and Mechanism (Part D: Developments in Enzyme Dynamics) Edited by Daniel L. Purich

Volume 250. Lipid Modifications of Proteins Edited by Patrick J. Casey and Janice E. Buss

Volume 251. Biothiols (Part A: Monothiols and Dithiols, Protein Thiols, and

Thiyl Radicals)

Edited by Lester Packer

Volume 252. Biothiols (Part B: Glutathione and Thioredoxin; Thiols in Signal Transduction and Gene Regulation) Edited by Lester Packer

Volume 253. Adhesion of Microbial Pathogens Edited by Ron J. Doyle and Itzhak Ofek

Volume 254. Oncogene Techniques

Edited by Peter K. Vogt and Inder M. Verma

Volume 255. Small GTPases and Their Regulators (Part A: Ras Family) Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 256. Small GTPases and Their Regulators (Part B: Rho Family) Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 257. Small GTPases and Their Regulators (Part C: Proteins Involved in Transport)

Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 258. Redox-Active Amino Acids in Biology Edited by Judith P. Klinman

Volume 259. Energetics of Biological Macromolecules Edited by Michael L. Johnson and Gary K. Ackers

Volume 260. Mitochondrial Biogenesis and Genetics (Part A) Edited by Giuseppe M. Attardi and Anne Chomyn

Volume 261. Nuclear Magnetic Resonance and Nucleic Acids Edited by Thomas L. James

Volume 262. DNA Replication Edited by Judith L. Campbell

Volume 263. Plasma Lipoproteins (Part C: Quantitation)

Edited by William A. Bradley, Sandra H. Gianturco, and Jere P. Segrest

Volume 264. Mitochondrial Biogenesis and Genetics (Part B) Edited by Giuseppe M. Attardi and Anne Chomyn

Volume 265. Cumulative Subject Index Volumes 228, 230-262

Volume 266. Computer Methods for Macromolecular Sequence Analysis Edited by Russell F. Doolittle

Volume 267. Combinatorial Chemistry Edited by John N. Abelson

Volume 268. Nitric Oxide (Part A: Sources and Detection of NO; NO Synthase)

Edited by Lester Packer

Volume 269. Nitric Oxide (Part B: Physiological and Pathological Processes) Edited by Lester Packer

Volume 270. High Resolution Separation and Analysis of Biological

Macromolecules (Part A: Fundamentals)

Edited by Barry L. Karger and William S. Hancock

Volume 271. High Resolution Separation and Analysis of Biological

Macromolecules (Part B: Applications)

Edited by Barry L. Karger and William S. Hancock

Volume 272. Cytochrome P450 (Part B)

Edited by Eric F. Johnson and Michael R. Waterman

Volume 273. RNA Polymerase and Associated Factors (Part A) Edited by Sankar Adhya

Volume 274. RNA Polymerase and Associated Factors (Part B) Edited by Sankar Adhya

Volume 275. Viral Polymerases and Related Proteins

Edited by Lawrence C. Kuo, David B. Olsen, and Steven S. Carroll

Volume 276. Macromolecular Crystallography (Part A) Edited by Charles W. Carter, Jr., and Robert M. Sweet

Volume 277. Macromolecular Crystallography (Part B) Edited by Charles W. Carter, Jr., and Robert M. Sweet

Volume 278. Fluorescence Spectroscopy

Edited by Ludwig Brand and Michael L. Johnson

Volume 279. Vitamins and Coenzymes (Part I)

Edited by Donald B. McCormick, John W. Suttie, and Conrad Wagner

Volume 280. Vitamins and Coenzymes (Part J)

Edited by Donald B. McCormick, John W. Suttie, and Conrad Wagner Volume 281. Vitamins and Coenzymes (Part K)

Edited by Donald B. McCormick, John W. Suttie, and Conrad Wagner Volume 282. Vitamins and Coenzymes (Part L)

Edited by Donald B. McCormick, John W. Suttie, and Conrad Wagner

Volume 283. Cell Cycle Control Edited by William G. Dunphy

Volume 284. Lipases (Part A: Biotechnology) Edited by Byron Rubin and Edward A. Dennis

Volume 285. Cumulative Subject Index Volumes 263, 264, 266-284, 286-289

Volume 286. Lipases (Part B: Enzyme Characterization and Utilization) Edited by Byron Rubin and Edward A. Dennis

Volume 287. Chemokines Edited by Richard Horuk

Volume 288. Chemokine Receptors Edited by Richard Horuk

Volume 289. Solid Phase Peptide Synthesis Edited by Gregg B. Fields

Volume 290. Molecular Chaperones

Edited by George H. Lorimer and Thomas Baldwin

Volume 291. Caged Compounds Edited by Gerard Marriott

Volume 292. ABC Transporters: Biochemical, Cellular, and Molecular Aspects

Edited by Suresh V. Ambudkar and Michael M. Gottesman

Volume 293. Ion Channels (Part B) Edited by P. Michael Conn

Volume 294. Ion Channels (Part C) Edited by P. Michael Conn

Volume 295. Energetics of Biological Macromolecules (Part B) Edited by Gary K. Ackers and Michael L. Johnson

Volume 296. Neurotransmitter Transporters Edited by Susan G. Amara

Volume 297. Photosynthesis: Molecular Biology of Energy Capture Edited by Lee McIntosh

Volume 298. Molecular Motors and the Cytoskeleton (Part B) Edited by Richard B. Vallee

Volume 299. Oxidants and Antioxidants (Part A) Edited by Lester Packer

Volume 300. Oxidants and Antioxidants (Part B) Edited by Lester Packer

Volume 301. Nitric Oxide: Biological and Antioxidant Activities (Part C) Edited by Lester Packer

Volume 302. Green Fluorescent Protein Edited by P. Michael Conn

Volume 303. cDNA Preparation and Display Edited by Sherman M. Weissman

Volume 304. Chromatin

Edited by Paul M. Wassarman and Alan P. Wolffe

Volume 305. Bioluminescence and Chemiluminescence (Part C) Edited by Thomas O. Baldwin and Miriam M. Ziegler

Volume 306. Expression of Recombinant Genes in Eukaryotic systems

Edited by Joseph C. Glorioso and Martin C. Schmidt

Volume 307. Confocal Microscopy Edited by P. Michael Conn

Volume 308. Enzyme Kinetics and Mechanism (Part E: Energetics of Enzyme Catalysis)

Edited by Daniel L. Purich and Vern L. Schramm

Volume 309. Amyloid, Prions, and Other Protein Aggregates Edited by Ronald Wetzel

Volume 310. Biofilms Edited by Ron J. Doyle

Volume 311. Sphingolipid Metabolism and Cell Signaling (Part A) Edited by Alfred H. Merrill, Jr., and Yusuf A. Hannun

Volume 312. Sphingolipid Metabolism and Cell Signaling (Part B) Edited by Alfred H. Merrill, Jr., and Yusuf A. Hannun

Volume 313. Antisense Technology (Part A: General Methods, Methods of Delivery, and RNA studies) Edited by M. Ian Phillips

Volume 314. Antisense Technology (Part B: Applications) Edited by M. Ian Phillips

Volume 315. Vertebrate Phototransduction and the Visual Cycle (Part A) Edited by Krzysztof Palczewski

Volume 316. Vertebrate Phototransduction and the Visual Cycle (Part B) Edited by Krzysztof Palczewski

Volume 317. RNA-Ligand Interactions (Part A: Structural Biology Methods) Edited by Daniel W. Celander and John N. Abelson

Volume 318. RNA-Ligand Interactions (Part B: Molecular Biology Methods) Edited by Daniel W. Celander and John N. Abelson

Volume 319. Singlet Oxygen, UV-A, and Ozone Edited by Lester Packer and Helmut Sies

Volume 320. Cumulative Subject Index Volumes 290-319

Volume 321. Numerical Computer Methods (Part C) Edited by Michael L. Johnson and Ludwig Brand

Volume 322. Apoptosis Edited by John C. Reed

Volume 323. Energetics of Biological Macromolecules (Part C) Edited by Michael L. Johnson and Gary K. Ackers

Volume 324. Branched-Chain Amino Acids (Part B) Edited by Robert A. Harris and John R. Sokatch

Volume 325. Regulators and Effectors of Small GTPases (Part D: Rho Family) Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 326. Applications of Chimeric Genes and Hybrid Proteins (Part A: Gene Expression and Protein Purification)

Edited by Jeremy Thorner, Scott D. Emr, and John N. Abelson

Volume 327. Applications of Chimeric Genes and Hybrid Proteins (Part B: Cell Biology and Physiology)

Edited by Jeremy Thorner, Scott D. Emr, and John N. Abelson

Volume 328. Applications of Chimeric Genes and Hybrid Proteins (Part C:

Protein-Protein Interactions and Genomics)

Edited by Jeremy Thorner, Scott D. Emr, and John N. Abelson

Volume 329. Regulators and Effectors of Small GTPases (Part E: GTPases Involved in Vesicular Traffic)

Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 330. Hyperthermophilic Enzymes (Part A) Edited by Michael W. W. Adams and Robert M. Kelly

Volume 331. Hyperthermophilic Enzymes (Part B) Edited by Michael W. W. Adams and Robert M. Kelly

Volume 332. Regulators and Effectors of Small GTPases (Part F: Ras Family I) Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 333. Regulators and Effectors of Small GTPases (Part G: Ras Family II) Edited by W. E. Balch, Channing J. Der, and Alan Hall

Volume 334. Hyperthermophilic Enzymes (Part C) Edited by Michael W. W. Adams and Robert M. Kelly

Volume 335. Flavonoids and Other Polyphenols Edited by Lester Packer

Volume 336. Microbial Growth in Biofilms (Part A: Developmental and Molecular Biological Aspects) Edited by Ron J. Doyle

Volume 337. Microbial Growth in Biofilms (Part B: Special Environments and Physicochemical Aspects) Edited by Ron J. Doyle

Volume 338. Nuclear Magnetic Resonance of Biological Macromolecules (Part A)

Edited by Thomas L. James, Volker Dotsch, and Uli Schmitz

Volume 339. Nuclear Magnetic Resonance of Biological Macromolecules (Part B)

Edited by Thomas L. James, Volker Dotsch, and Uli Schmitz

Volume 340. Drug-Nucleic Acid Interactions

Edited by Jonathan B. Chaires and Michael J. Waring

Volume 341. Ribonucleases (Part A) Edited by Allen W. Nicholson

Volume 342. Ribonucleases (Part B) Edited by Allen W. Nicholson

Volume 343. G Protein Pathways (Part A: Receptors) Edited by Ravi Iyengar and John D. Hildebrandt

Volume 344. G Protein Pathways (Part B: G Proteins and Their Regulators) Edited by Ravi Iyengar and John D. Hildebrandt

Volume 345. G Protein Pathways (Part C: Effector Mechanisms) Edited by Ravi Iyengar and John D. Hildebrandt

Volume 346. Gene Therapy Methods Edited by M. Ian Phillips

Volume 347. Protein Sensors and Reactive Oxygen Species (Part A:

Selenoproteins and Thioredoxin)

Edited by Helmut Sies and Lester Packer

Volume 348. Protein Sensors and Reactive Oxygen Species (Part B: Thiol

Enzymes and Proteins)

Edited by Helmut Sies and Lester Packer

Volume 349. Superoxide Dismutase Edited by Lester Packer

Volume 350. Guide to Yeast Genetics and Molecular and Cell Biology (Part B) Edited by Christine Guthrie and Gerald R. Fink

Volume 351. Guide to Yeast Genetics and Molecular and Cell Biology (Part C) Edited by Christine Guthrie and Gerald R. Fink

Volume 352. Redox Cell Biology and Genetics (Part A) Edited by Chandan K. Sen and Lester Packer

Volume 353. Redox Cell Biology and Genetics (Part B) Edited by Chandan K. Sen and Lester Packer

Volume 354. Enzyme Kinetics and Mechanisms (Part F: Detection and Characterization of Enzyme Reaction intermediates) Edited by Daniel L. Purich

Volume 355. Cumulative Subject Index Volumes 321-354

Volume 356. Laser Capture Microscopy and Microdissection Edited by P. Michael Conn

Volume 357. Cytochrome P450, Part C

Edited by Eric F. Johnson and Michael R. Waterman

Volume 358. Bacterial Pathogenesis (Part C: Identification, Regulation, and

Function of Virulence Factors)

Edited by Virginia L. Clark and Patrik M. Bavoil

Volume 359. Nitric Oxide (Part D)

Edited by Enrique Cadenas and Lester Packer

Volume 360. Biophotonics (Part A) Edited by Gerard Marriott and Ian Parker

Volume 361. Biophotonics (Part B) Edited by Gerard Marriott and Ian Parker

Volume 362. Recognition of Carbohydrates in Biological Systems (Part A) Edited by Yuan C. Lee and Reiko T. Lee

Volume 363. Recognition of Carbohydrates in Biological Systems (Part B) Edited by Yuan C. Lee and Reiko T. Lee

Volume 364. Nuclear Receptors

Edited by David W. Russell and David J. Mangelsdorf

Volume 365. Differentiation of Embryonic Stem Cells Edited by Paul M. Wassauman and Gordon M. Keller

Volume 366. Protein Phosphatases

Edited by Susanne Klumpp and Josef Krieglstein

Volume 367. Liposomes (Part A) Edited by Nejat DUzgUnes

Volume 368. Macromolecular Crystallography (Part C) Edited by Charles W. Carter, Jr., and Robert M. Sweet

Volume 369. Combinational Chemistry (Part B) Edited by Guillermo A. Morales and Barry A. Bunin

Volume 370. RNA Polymerases and Associated Factors (Part C) Edited by Sankar L. Adhya and Susan Garges

Volume 371. RNA Polymerases and Associated Factors (Part D) Edited by Sankar L. Adhya and Susan Garges

Volume 372. Liposomes (Part B) Edited by Nejat Duzgunes

Volume 373. Liposomes (Part C) Edited by Nejat Duzgunes

Volume 374. Macromolecular Crystallography (Part D) Edited by Charles W. Carter, Jr., and Robert W. Sweet

Volume 375. Chromatin and Chromatin Remodeling Enzymes Edited by C. David Allis and Carl Wu

Volume 376. Chromatin and Chromatin Remodeling Enzymes Edited by C. David Allis and Carl Wu

Volume 377. Chromatin and Chromatin Remodeling Enzymes Edited by C. David Allis and Carl Wu

Volume 378. Quinones and Quinone Enzymes (Part A) Edited by Helmut Sies and Lester Packer

Volume 379. Energetics of Biological Macromolecules (Part D) Edited by Jo M. Holt, Michael L. Johnson, and Gary K. Ackers

Volume 380. Energetics of Biological Macromolecules (Part E) Edited by Jo M. Holt, Michael L. Johnson, and Gary K. Ackers

Volume 381. Oxygen Sensing

Edited by Chandan K. Sen and Gregg L. Semenza

Volume 382. Quinones and Quinone Enzymes (Part B) Edited by Helmut Sies and Lester Packer

Volume 383. Numerical Computer Methods (Part D) Edited by Ludwig Brand and Michael L. Johnson

Volume 384. Numerical Computer Methods (Part E) Edited by Ludwig Brand and Michael L. Johnson

Volume 385. Imaging in Biological Research (Part A) Edited by P. Michael Conn

Volume 386. Imaging in Biological Research (Part B) Edited by P. Michael Conn

Volume 387. Liposomes (Part D) Edited by Nejat Duzgunes

Volume 388. Protein Engineering

Edited by Dan E. Robertson and Joseph P. Noel

Volume 389. Regulators of G-Protein Signaling (Part A) Edited by David P. Siderovski

Volume 390. Regulators of G-Protein Signaling (Part B) Edited by David P. Siderovski

Volume 391. Liposomes (Part E) Edited by Nejat DUzgUnes

Volume 392. RNA Interference Edited by Engelke Rossi

Volume 393. Circadian Rhythms Edited by Michael W. Young

Volume 394. Nuclear Magnetic Resonance of Biological Macromolecules (Part C)

Edited by Thomas L. James

Volume 395. Producing the Biochemical Data (Part B) Edited by Elizabeth A. Zimmer and Eric H. Roalson

Volume 396. Nitric Oxide (Part E)

Edited by Lester Packer and Enrique Cadenas

Volume 397. Environmental Microbiology Edited by Jared R. Leadbetter

Volume 398. Ubiquitin and Protein Degradation (Part A) Edited by Raymond J. Deshaies

Volume 399. Ubiquitin and Protein Degradation (Part B) Edited by Raymond J. Deshaies

Volume 400. Phase II Conjugation Enzymes and Transport Systems Edited by Helmut Sies and Lester Packer

Volume 401. Glutathione Transferases and Gamma Glutamyl Transpeptidases Edited by Helmut Sies and Lester Packer

Volume 402. Biological Mass Spectrometry Edited by A. L. Burlingame

Volume 403. GTPases Regulating Membrane Targeting and Fusion Edited by William E. Balch, Channing J. Der, and Alan Hall

Volume 404. GTPases Regulating Membrane Dynamics Edited by William E. Balch, Channing J. Der, and Alan Hall

Volume 405. Mass Spectrometry: Modified Proteins and Glycoconjugates Edited by A. L. Burlingame

Volume 406. Regulators and Effectors of Small GTPases: Rho Family Edited by William E. Balch, Channing J. Der, and Alan Hall

Volume 407. Regulators and Effectors of Small GTPases: Ras Family Edited by William E. Balch, Channing J. Der, and Alan Hall

Volume 408. DNA Repair (Part A)

Edited by Judith L. Campbell and Paul Modrich

Volume 409. DNA Repair (Part B)

Edited by Judith L. Campbell and Paul Modrich

Volume 410. DNA Microarrays (Part A: Array Platforms and Web-Bench Protocols)

Edited by Alan Kimmel and Brian Oliver

Volume 411. DNA Microarrays (Part B: Databases and Statistics) Edited by Alan Kimmel and Brian Oliver

Volume 412. Amyloid, Prions, and Other Protein Aggregates (Part B) Edited by Indu Kheterpal and Ronald Wetzel

Volume 413. Amyloid, Prions, and Other Protein Aggregates (Part C) Edited by Indu Kheterpal and Ronald Wetzel

Volume 414. Measuring Biological Responses with Automated Microscopy Edited by James Inglese

Volume 415. Glycobiology Edited by Minoru Fukuda

Volume 416. Glycomics Edited by Minoru Fukuda

Volume 417. Functional Glycomics Edited by Minoru Fukuda

Volume 418. Embryonic Stem Cells

Edited by Irina Klimanskaya and Robert Lanza

Volume 419. Adult Stem Cells

Edited by Irina Klimanskaya and Robert Lanza

Volume 420. Stem Cell Tools and Other Experimental Protocols (in preparation)

Edited by Irina Klimanskaya and Robert Lanza

Volume 421. Advanced Bacterial Genetics: Use of Transposons and Phage for Genomic Engineering (in preparation) Edited by Kelly T. Hughes

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