Contributors

Airenne Department of Molecular Medicine, AI Virtanen Institute, University of Kuopio, and Ark Therapeutics Oy, Kuopio, Finland Kurosh Ameri Cancer Research UK, Molecular Oncology Laboratories, Weatheral Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom Helen A. Andersson Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, U.S.A. W. French Anderson Norris Cancer Center, University of Southern California Keck School of Medicine, Los...

References

Adenovirus-mediated in vivo gene transfer. Ann N Y Acad Sci 1994 716 90-101. 2. Bramson JL, Graham FL, Gauldie J. The use of adenoviral vectors for gene therapy and gene transfer in vivo. Curr Opin Biotechnol 1995 6 590-595. 3. Trapnell BC, Gorziglia M. Gene therapy using adenoviral vectors. Curr Opin Biotechnol 1994 5 617-625. 4. Kozarsky KF, Wilson JM. Gene therapy Adenovirus vectors. Curr Opin Genet Dev 1993 3 499-503. 5. Hackett NR, Kaminsky SM, Sondhi D, Crystal RG....

Seroswitch Vectors

The induction of neutralizing antibodies is presumably one of the barriers against successful readministration of the same Ad gene transfer vector. In experimental animals, this has been observed for intravenous (111), intratracheal (71,112), and intraperitoneal (34) administration where the vector is exposed to antibodies prior to contact with the tissue. Effective readministration of the same vector has also been demonstrated to be impossible using direct tissue injection (113). Because prior...