Pioneering studies in inducible and conditional transgene expression have brought about the development of a wide variety of controlled gene expression systems. Among them, the tetracy-cline-controlled expression systems have been used extensively in vitro and in vivo. In recent years, some strategies derived from tetracycline-inducible system alone, as well as the combined use of Tet-based systems and Cre/lox P switching gene expression system, have been newly developed to allow for more flexibility in exploring gene functions. The reported successes in using the tetracycline-inducible system in transgenic mice have led to the development of more sophisticated strategies for manipulating target gene expression (Stieger et al., 2009).
All existing inducible genetic models have thus regulated expression of the transgenes in neurons only. However, recent studies have demonstrated
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