Summary

As schizophrenia is a disorder of the association cortices, primate models will be important for understanding the impact of genetic insults on the elaborate neuronal architecture and cortical circuitry distinct to the primate brain. The advent of AAV technology provides the opportunity to study genetic changes in primate brain, and will serve as an important bridge between rodent models and pathological profiles in patients, particularly when there have been negative findings in rodent models.

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