Conclusions

In this chapter we aimed to provide a comprehensive overview of contemporary methodological approaches to identification of genes for complex traits and diseases. Nowadays association analysis, particularly through GWA scans, is the preferred tool. Within a few years it will be feasible to obtain complete human sequence data at relatively low cost (i.e., <$1000), which may render large-scale SNP genotyping - although developed only recently - a technique of the past. Future GWA studies will face major computational challenges in meaningfully relating complete sequence data to disease susceptibility traits, but offer the prospect of revealing parts of the missing heritability.

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