Catalytic Antibodies

Antibodies possessing catalytic activity as a result of their selection using transition state mimics as immuno-genic or antigenic agents. Antibody catalysis takes advantage of the molecular diversity of the immune system and current knowledge of mechanistic enzymology and physical organic chemistry1 , allowing production of novel catalysts for reactions previously lacking biological catalysis. As pointed out by Schultz and Lerner1 , systematic mechanistic and structural investigations of...