I greatly acknowledge the contributions of Junzo Uchiyama, Irina Zhdanova, and Shintaro Imamura to this work. I am grateful to Peter Bayliss and Eriko Koshimizu for their contributions in our laboratory. I am also very grateful to Thomas Roberts for his support and continued encouragement. I really thank Andre Rosowsky for his critical reading of this manuscript. Finally, I thank Junko Kishi, Shunsuke Kishi, and Shota Kishi for their helpful preparation of this manuscript. This work is funded by research grants from A-T Children's Project, the Ellison Medical Foundation, and NIA/NIH to S.K.
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