The application and development of high-throughput technologies in aging-related research have the potential to dramatically enhance our understanding of human aging. Microarray studies are beginning to identify conserved age-associated transcriptional changes across model systems, and the identification of bona fide gene expression biomarkers will be essential for testing putative antiaging therapies in people.
Accelerated assays for measuring life span in simple eukaryotes will provide additional candidates for longevity studies in mammals. Genome-wide attempts to identify genetic polymorphisms associated with human longevity have already uncovered important age-associated disease alleles, and will perhaps result in candidate aging genes in people.
Indeed, there is reason to be optimistic that continued application of these new technologies will enhance our understanding of the molecular biology of aging and, ultimately, our ability to treat age-associated disease.
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When over eighty years of age, the poet Bryant said that he had added more than ten years to his life by taking a simple exercise while dressing in the morning. Those who knew Bryant and the facts of his life never doubted the truth of this statement.