Contents

Longevity Blueprint

Longevity Health and Wellness Protocol

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xi II. General Methods

Contributors Preface xxi

I. Introduction

1. Historical Development of Animal

Models of Aging 1

Richard L. Sprott and Steven N. Austad

2. Species Selection in Comparative Studies of Aging and Antiaging Research 9

Joao Pedro de Magalhaes

3. Principles of Animal Use for

Gerontological Research 21

Richard A. Miller

4. From Primary Cultures to the Aging Organism: Lessons from Human

T Lymphocytes 33

Rita B. Effros

5. Models of Systems Failure in Aging 45 Leonid A. Gavrilov and Natalia S. Gavrilova

6. Major Issues in Ethics of Aging

Research 69

Michael D. Smith

7. Ethical Aspects of Research Involving

Elderly Persons 79

Paul S. Mueller and C. Christopher Hook

8. SAGE KE and Other Online Sources

Related to Aging 93

Evelyn Strauss and R. John Davenport

9. Proteomics in Aging Research 99

Christian Schoneich

10. Application of High-Throughput Technologies to Aging-Related

Research 109

Matt Kaeberlein

11. Models of Alzheimer's Disease 121

Harry LeVine III and Lary C. Walker

12. Age-Related Hippocampal Dysfunction: Early Alzheimer's

Disease vs. Normal Aging 135

Scott A. Small

13. Epidemiology in Aging Research 143

Hermann Brenner and Volker Arndt

14. Statistical Issues for Longevity Studies in Animal Models 153

Chenxi Wang, Scott W. Keith, Kevin R. Fontaine, and David B. Allison

15. Models for the Study of Infection in Populations 165

John R. Williams

16. Estimation of the Rate of Production of Oxygen Radicals by Mitochondria 183

Alberto Sanz and Gustavo Barja

III. Animal Models

A. Non-mammalian Systems

17. Telomeres and Aging in the Yeast

Model System 191

Kurt W. Runge

18. Longevity and Aging in Budding

Yeast 207

Matt Kaeberlein

19. From Yeast Methuselah Genes to

Evolutionary Medicine 219

Paola Fabrizio and Valter D. Longo

20. Strongyloides ratti: A Nematode with

Extraordinary Plasticity in Aging 229

Michael P. Gardner, David Gems, and Mark E. Viney

21. Insect Models for the Study of Aging 241

Klaus-Gunter Collatz

22. Drosophila Models of Aging 253

Satomi Miwa and Alan Cohen

23. Models of Aging in Honeybee

Workers 267

Gro V. Amdam and Olav Rueppell

24. Ants as Naturally Long-lived

Insect Models for Aging 277

Joel D. Parker and Karen M. Parker

25. Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogaster 283

Robert Arking

26. Annual Fish as a Genetic Model for Aging 301

Pudur Jagadeeswaran

27. The Use of Mature Zebrafish (Danio rerio) as a Model for

Human Aging and Disease 309

Evan T. Keller, Jill M. Keller, and Gavin Gillespie

28. Zebrafish as Aging Models 317

Shuji Kishi

29. Telomeres in Aging: Birds 339

Susan E. Swanberg and Mary E. Delany

30. Domestic and Wild Bird Models for the Study of Aging 351

Donna J. Holmes and Mary Ann Ottinger

B. Mammalian Systems

31. A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie

Restriction 367

Isao Shimokawa

32. Rat Models of Age-Related Cognitive

Decline 379

Jennifer L. Bizon and Michelle M. Nicolle

33. Aged Rodents for Biogerontology

Research 393

Nancy L. Nadon

34. Life Extension in the Dwarf

Mouse 403

Andrzej Bartke

35. The Canine Model of Human Brain Aging: Cognition, Behavior, and

Neuropathology 415

P. Dwight Tapp and Christina T. Siwak

36. Bats as a Novel Model for Aging

Research 435

Anja K. Brunet-Rossinni and Rocco E. Rossinni

37. Memory in the Aging Hippocampus:

What Can Place Cells Tell Us? 447

Iain A. Wilson

38. The Rhesus Macaque as a Model of Human Aging and Age-Related

Disease 457

Mary Ann Ottinger, Julie A. Mattison, Mary B. Zelinski, Julie M. Wu,

Steven G. Kohama, George S. Roth, Mark A. Lane, and Donald K. Ingram

39. Nonhuman Primates as a Models for Reproductive Aging and

Human Infertility 469

Barry D. Bavister and Carol A. Brenner

Viii

IV. Comparative Models

40. Neurobiology of the Aging

Brain 485

Carlo Bertoni-Freddari, Patrizia Fattoretti, Tiziana Casoli, and Giuseppina Di Stefano

41. Mitochondrial DNA and Aging 507

Mikhail Alexeyev, Susan P. LeDoux, and Glenn L. Wilson

42. Models for Apoptosis: From Newborn to Adult 521

Christiane Charriaut-Marlangue and Sylvain Renolleau

43. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive

Senescence 533

Jacqueline A. Maffucci and Andrea C. Gore

44. Models of Chaperones in Aging 553

Jens Krell and J. O. Nehlin

45. Therapeutic Potential of Stem Cells in Aging-Related Diseases 563

Shannon Whirledge, Kirk C. Lo, and Dolores J. Lamb 46. Nuclear Transfer and

Cloning: Preservaton or Expansion of Proliferative Lifespan? 575

Keith E. Latham

47. Human Models of Longevity 585

Thomas Perls

48. Computational Models of Mitochondrial

DNA in Aging 591

David C. Samuels

49. Mouse Models of Accelerated

Aging 601

Jan Vijg and Paul Hasty

51. Fertility and Aging Men: An Introduction to the Male Biological Clock 631

Peter N. Schlegel, Puneet Masson, Sarah M. Lambert, and Harry Fisch

52. Benign Prostatic Hyperplasia 641

Peter Celec

53. Murine Models of Infectious Diseases in the Aged 651

Kevin P. High

54. Studying Infection in the Elderly: Physiopathology, Clinical Symptoms and

Causative Agents of Pneumonia 661

Jean-Paul Janssens

55. Diabetes and Aging 671

Tamas FUlop, Anis Larbi, Daniel Tessier, and André Carpentier

56. Diabetes as a Model of Premature

Aging 687

Arshag D. Mooradian

57. Frailty as a Model of Aging 697

Jeremy D. Walston

58. Osteoporosis and Cardiovascular

Disease in the Elderly 703

Samy I. McFarlane, John Nicasio, and Ranganath Muniyappa

59. Depression in Older Patients 713

Kiran Rabheru

60. The Aging Human Lung: Age-Associated Changes in Structure and Function 727

Keith C. Meyer

61. Iceland as a Model for Human

Aging 735

Adalsteinn Gudmundsson and Pailmi V. Jonsson

62. Behavior and Personality in the

Study of Successful Aging 741

Judith Corr and Loraine Tarou

V. Disease-States and Normal Aging

A. Disease States

50. Models, Definitions, and Criteria of

Frailty 619

David B. Hogan

B. Health Issues Affecting the Elderly

63. Andropause 749

Rabih Hijazi and Glenn R. Cunningham

64. Aging and the Perceptual Organization of Sounds: A Change of Scene? 759

Claude Alain, Benjamin J. Dyson, and Joel S. Snyder

65. Models of Immune Function in Aging 771

Christopher A. Jolly and Zhun Xu

66. Human T Cell Clones in Long-Term Culture as Models for the Impact of Chronic Antigenic Stress in Aging 781

Graham Pawelec, Erminia Mariani, Rafael Solana, Rosalyn Forsey, Anis Larbi, Simone Neri, Olga Dela Rosa, Yvonne Barnett, Jon Tolson, and Tamas Fulo'p

67. Age-Related Changes in the

Human Retina 793

Carlo Cavallotti and Nicola Pescosolido

68. Models of Age-Related Vision

Problems 813

J. Fielding Hejtmancik, Mark Kantorow, and Takeshi Iwata

69. Health, Functional and Therapeutic Implications of

Obesity in Aging 829

70. Age and Joints 841

Klaus Bobacz and Ilse-Gerlinde Sunk

71. Sleep Quality in the Elderly 853

Ragnar Asplund

72. Atherogenesis and Aging 865

Cam Patterson

73. Managing Menopausal Symptoms 873

Mary Ellen Rousseau

74. Psychological Aging: A Contextual View 881

Hans-Werner Wahl and Frieder R. Lang

75. Nutrients and Aging 897

Lawrence J. Whalley

C. Approaches to Treatment and Models

76. Methods for Studying Hearing Impairment and Auditory Problems of the Aged 911

Robert D. Frisina and D. Robert Frisina

77. A Model for Understanding the Pathomechanics of Osteoarthritis in Aging 923

Thomas P. Andriacchi and Annegret Mundermann

78. Aging and Cardiovascular

Angiogenesis Models 937

Andrew Chin, Jacquelyn M. Holm,

Inga J. Duignan, and Jay M. Edelberg

79. Models for the Study of Stroke 947

Thiruma V. Arumugam and

Mark P. Mattson

80. Werner Syndrome as a Model of Human Aging 961

Raymond J. Monnat, Jr.

81. Models of Sarcopenia 977

Alfred L. Fisher

82. Aging of Human Skin 993

Paolo U. Giacomoni

83. Models of Hypertension in Aging 999

Jane F. Reckelhoff, Radu Iliescu, Licy Yanes, and Lourdes A. Fortepiani

Glossary 1011

Index 1041

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