Identification of Biomarkers of Zebrafish Aging and Senescence

As has already been mentioned, compared with other model organisms, the aging process of zebrafish is in a very early stage of investigation, and we are currently unable to tell precisely how the fish age physiologically, and what the pathophysiological symptoms and lesions are, in zebrafish aging and in their age-associated diseases, respectively. Therefore, first and foremost, it is important to set forth some principles for evaluating the functional aging process in zebrafish.

To determine effective biomarkers of aging in zebra-fish, we have analyzed the following potential markers in zebrafish aging: (a) age-dependent accumulation of oxidative damage in proteins and lipofuscin accumulation (oxidation aging marker); (b) senescence-associated galactosidase (SA-3-gal) activity (enzymatic aging marker); (c) age-dependent telomere length and metabolism, and telomerase activity (telomeric aging marker); (d) age-dependent competence for caudal (tail) fin regeneration (regeneration aging marker); (e) age-associated growth rate and size in a restricted space and time period (growth size aging marker); (f) age-related changes in locomotor activity (behavioral aging marker) and age-dependent changes of activity in circadian rhythm and decline of melatonin secretion (circadian aging marker).

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