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aSpecies are typically listed according to their evolutionary distance to humans. bMaximum lifespan in years.

cAge at sexual maturity in years. Typical or range of values is displayed.

dAdult body mass (M), a standard measure of body size, in kilograms. Typical or range of values is displayed.

aSpecies are typically listed according to their evolutionary distance to humans. bMaximum lifespan in years.

cAge at sexual maturity in years. Typical or range of values is displayed.

dAdult body mass (M), a standard measure of body size, in kilograms. Typical or range of values is displayed.

glaber), which may live up to 28 years, could be useful models. Likewise, while mice and rats are short-lived, some species of the Muridae family can live up to 10 years or more, namely, the slender-tailed cloud rat (Phloeomys cumingi) and the muskrat (Ondatra zibethicus). The phenotypic variation we witness across mammalian orders may bias comparative studies of aging, so again primates and rodents should be preferred (Table 2.1). Of course, we can consider other mammalian orders, and for practical reasons these may even be necessary. Still, I maintain my opinion that studies, such as comparative genomics studies, based on primates and rodents should suffice to study aging and are the most appropriate to identify genetic factors influencing human aging.

Putative Models of Antiaging Strategies

Due to obvious practical and economical reasons, the most widely employed models of aging are short-lived. It has been argued, however, that studying short-lived species may be irrelevant to humans because whatever mechanisms limit the lifespans of these species have been evolutionarily "solved" by long-lived species like us.

Studying long-lived species may then be potentially more beneficial to people (Strehler, 1986).

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