The process of biological aging is a complex phenomenon, depending on a manifold of different parameters, including nature of the organism, lifestyle, diet, and so forth. In order to compare different aging phenotypes, a global qualitative and quantitative proteomic analysis of different species is necessary. Proteomic data need to be interpreted relative to complementary genomic and functional analysis. The present article surveys several proteomic methods and their direct application andjor potential relevance for the characterization of the ''aging proteome.'' Specific emphasis has been given to the analysis of post-translational protein modifications.
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