An extensive discussion of the systemic manifestations of HIV/AIDS would be quite lengthy and beyond the scope of this chapter. Note will be made of the PHI, which presents with fever, myalgias, pharyngitis, arthralgias, headache, and malaise. Nonpruritic maculo-papular rash of the face and trunk is reported in 30% to 70% of cases (10) Generalized lymphadenopathy, nausea, vomiting, neurological complications, oral ulceration, and candidiasis might be observed. Since PHI can present before antibody test seroconversion, diagnostic testing should utilize measurement of specific viral antigens or viral load for detection of HIV infection.
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