Nasal NK/T-cell lymphoma is localized in its initial stages in 80% of patients; however, it can disseminate early. Prognosis is usually poor (35). The International Prognostic Index (IPI), predictive of treatment outcome in malignant lymphomas of different grades and subtypes, has been applied for this type of lymphoma. It has been suggested that patients with high IPI scores, and therefore a worse prognosis, may benefit from additional therapy to prevent relapses (39). Systemic progression is usually fatal. Life-long follow-up is recommended for all patients, in view of the possibility of delayed relapse.
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