Complications of eosinophilic fungal rhinosinusitis or CRS are uncommon because most acute exacerbations are bacterial and are successfully treated with antibiotics. Rarely, patients can progress to frontal bone osteomyelitis. Extensive polyps can thin out and erode bone, altering facial structure and resulting in orbital and anterior cranial fossa dehiscence. Orbital complications, including preseptal and orbital cellulitis and subperiosteal abscess, still occur. These patients must be started on intravenous antibiotics and evaluated for surgical intervention. More serious complications include cavernous sinus thrombophlebitis, meningitis, epidural abscess, and brain abscess (5).
The prognosis for this group of patients is optimistic. Those patients with a propensity to develop polyps will require revision surgery in the future, because polyp recurrence is generally the rule; however, their quality of life can be dramatically improved with appropriate medical and surgical intervention.
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