Definition

SJS was first described in 1922 by two American physicians, Stevens and Johnson, who reported an acute mucocutaneous syndrome characterized by severe purulent conjunctivitis, severe stomatitis, extensive mucosal necrosis, and skin lesions of erythema multiforme (EM) in two young boys. SJS was later designated EM major by Bernard Thomas in 1950, but this designation is not currently accepted, as SJS and EM are now considered distinct disorders.

SJS is a rapidly progressive mucocutaneous eruption usually preceded by a respiratory illness, characterized by severe erosions of at least two mucosal surfaces with variable skin involvement ranging from erythematous macules to bullae and skin necrosis, and accompanied by fever, lymphadenopathy, and toxicity (12).

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