Definition

Glucagon-secreting tumors of the pancreatic islets (glucagonomas) produce a distinctive syndrome characterized by the development of prominent mucocutaneous findings, adult-onset diabetes mellitus, weight loss, and anemia (18). Becker initially described the constellation of symptoms associated with an islet tumor of the pancreas in 1942.

The cutaneous component of this syndrome, termed necrolytic migratory erythema (NME), was first described by Wilkinson in his report of a patient with pancreatic carcinoma in 1973. The full syndrome was finally described by Mallison in 1974 in his review of nine patients with glucagon-secreting tumors.

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