Diagnosis And Staging Lymphoma

When lymphoma is suspected, a tissue diagnosis is required. Tissue biopsies should be large enough to provide adequate tissue for flow cytometry and molecular marker studies. For nodal lymphomas, excisional biopsy is recommended, although incisional biopsy is acceptable for large masses fixed to vital structures. For extranodal lymphomas, lymph nodes are not usually the source of material, and FNA and/or incisional biopsy are the preferred tissue-sampling methods. Frequently, an FNA will result in a tissue sample that is inadequate for definitive diagnosis and complete characterization. Flow cytometry should always be performed, especially if only an FNA is performed. Some very cellular aspirates may provide enough material to obviate the need for open biopsy. Care should be taken to handle the tissue gently, avoiding crush artifact. Specimens should be delivered fresh,

FIGURE 5 Patient with treated AML with complete right facial paralysis of eight months' duration. The paralysis did not improve after successful treatment of the leukemia. Abbreviation: AML, acute myeloblasts leukemia.

FIGURE 5 Patient with treated AML with complete right facial paralysis of eight months' duration. The paralysis did not improve after successful treatment of the leukemia. Abbreviation: AML, acute myeloblasts leukemia.

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