While sarcoidosis has an unknown etiology, it is postulated to result from exposure to environmental agents in a genetically susceptible host. This hypothesis is supported by racial differences and clusters of disease, implying a genetic predisposition, and the immunophenotype of an antigen-driven response with restricted T-cell receptor usage. Studies throughout the world reveal different genetic associations depending on ethnicity; the most commonly associated genes are class I HLA-A1 and -B8 and class II HLA-DR3. The mode of inheritance is likely polygenic (30,32).
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.