Pathogenesis

PJS is caused by a mutation in the LKB1 (also known as STK11) gene, a serine threonine kinase, which has been mapped to chromosome 19p13.3 and is thought to be a tumor-suppressor gene. LKB1 is a multifunctional kinase, which has been found to play a role in chromatin remodeling, cell cycle arrest, Wnt signaling, cell polarity, and energy metabolism. Mutations of this gene may interfere with its function as a tumor suppressor, but the signaling mechanisms that lead to PJS-related malignancies are not yet well understood (9).

Boost Your Metabolism and Burn Fat

Boost Your Metabolism and Burn Fat

Metabolism. There isn’t perhaps a more frequently used word in the weight loss (and weight gain) vocabulary than this. Indeed, it’s not uncommon to overhear people talking about their struggles or triumphs over the holiday bulge or love handles in terms of whether their metabolism is working, or not.

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