PJS is caused by a mutation in the LKB1 (also known as STK11) gene, a serine threonine kinase, which has been mapped to chromosome 19p13.3 and is thought to be a tumor-suppressor gene. LKB1 is a multifunctional kinase, which has been found to play a role in chromatin remodeling, cell cycle arrest, Wnt signaling, cell polarity, and energy metabolism. Mutations of this gene may interfere with its function as a tumor suppressor, but the signaling mechanisms that lead to PJS-related malignancies are not yet well understood (9).

Your Metabolism - What You Need To Know

Your Metabolism - What You Need To Know

If you have heard about metabolism, chances are it is in relation to weight loss. Metabolism is bigger than weight loss, though, as you will learn later on. It is about a healthier, better you. If you want to fire up your metabolism and do not have any idea how to do it, you have come to the right place. If you have tried to speed up your metabolism before but do not see visible results, you have also come to the right place.

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