Melanoma can occur as an autosomal-dominant familial syndrome in approximately 8% to 12% of all cases (3). These families are at overall increased risk of developing melanoma and will frequently develop multiple primary lesions at an earlier age. The cutaneous malignant melanoma-dysplastic nevi syndrome reflects a genetic abnormality located on the short arm of chromosome 1. Malignant melanoma cells frequently show this chromosomal 1 deletion, which results in loss of tumor suppression.
Like other skin cancers, melanoma has been associated with sun exposure. The incidence of melanoma is higher in regions of the world with higher ultraviolet light exposure. Increased rates of melanoma occur in populations with fair complexions. Blond or red-haired individuals with fair skin who sunburn easily are at greatest risk. People with multiple nevi also are more likely to develop melanoma. Areas of the body less protected by clothes, such as scalp, ears, and nose, are at increased risk. However, melanoma can occur on areas with minimal sun exposure and in individuals with darker skin tones; therefore, the actual etiology is thought to be multifactorial.
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.