Langerhans cells are the pathognomonic cells for LCH and are located throughout the reticuloendothelial system. They express HLA-DR, S-100, and CD1a (Fig. 1A and B). The pathological hallmarks of these cells are "Birbeck" granules, which are rod-like structures with dilated terminal ends identified by electron microscopy (EM). The immunohistochemical identification of HLA-DR, S-100, and CD1a receptors has replaced EM identification. LCH appears to be a myeloproliferative disease due to changes in gene structure. The inciting events are unclear, but infection could be a contributing factor (3).
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.