Pathologic changes seen in the synovium in RA consist of nonspecific inflammation and increases in synoviocytes. Lymphocytes and macrophages infiltrate affected joints, and lymphoid follicles with germinal centers of proliferating B cells surrounding dendritic cells can be seen. These pathogenetic changes may be seen within rheumatoid nodules that can occur in any organ. Further neoangiogenesis and synovial lining hyperplasia lead to destruction of cartilage and bone. In other organs, inflammatory infiltrates, vasculopathy, and fibrosis may be present as well.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.