Leprosy is a slowly progressive, chronic infectious disease caused by M. leprae. The lesions of leprosy have a predilection for peripheral nerves and skin. Leprosy is a serious health issue in developing countries, and early diagnosis followed by prompt therapy is paramount in the strategy to control this chronic infectious disease.

TABLE 3 World Health Organization Recommended Multidrug Therapy Regimens

Multibacillary leprosy

Paucibacillary leprosy

Paucibacillary leprosy

( 5 lesions)

(2-5 lesions)

(single lesion)

Rifampicin: 600 mg once

Rifampicin: 600 mg once

Single dose of:

a month

a month

Rifampicin: 600 mg

Dapsone: 100 mg daily

Dapsone: 100 mg daily

Ofloxacin: 400 mg

Clofazimine: 300 mg once

Duration = 6 mo

Minocycline: 100 mg

a month and 50 mg daily


Duration = 12 mo

10-14 yr old

Dose adjustments for children:

Rifampicin: 450 mg/mo

<10 yrold

Dapsone: 50 mg/day

Rifampicin: 300 mg/mo

Clofazimine: 150 mg/mo and 50 mg

Dapsone: 25 mg/day

every other day

Clofazimine: 100 mg/mo

and 50 mg twice/wk

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