Head and neck manifestations are very common in WG and may result in significant morbidity. WG is commonly associated with PR3-ANCA and is highly responsive to treatment with GC and cytotoxic agents. Modern therapy has reduced mortality from WG, from 50% within five months to less than 20% over at least eight years of follow-up. However, disease- and treatment-related morbidity is considerable. The notion that current therapies cure WG has been abandoned for the more realistic view that therapy is life-saving and converts a usually fatal disease to a chronic one.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.