Patients with metastatic melanoma may receive a number of treatment modalities. Solitary or few metastases in solid organs such as lung, small bowel, or liver can be treated with surgical excision. This is particularly effective for patients with a prolonged disease-free interval, characterized by a tumor doubling time of >60 days. Brain metastases can be managed with surgical excision or gamma knife radiation. Systemic immunotherapy and chemotherapy are options. Immunotherapy with interferon-a-2b has resulted in objective response rates in 7% to 23% of patients with stage IV disease (3). Interleukin-2-based regimens have had overall response rates of 21% to 24% (3). Responses to multiagent chemotherapy with dacarbazine (DTIC) are 10% to 53% in phase II trials (3), but combination treatments have not been superior in multicenter randomized trials (13,14). Metastatic melanoma continues to be an area of ongoing research for better systemic treatments.
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Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.