fatty acids) , contribute to pacify and stabilise the dangerous lesions. In that regard, it is noteworthy that moderate alcohol consumption, a well-known cardioprotective factor, was recently shown to be associated with low blood levels of systemic markers of inflammation,109 suggesting a new protective mechanism to explain the inverse relationship between alcohol and CHD rate. In the same line, the potential of dietary n-3 fatty acids to reduce the production of inflammatory cytokines79,80 by leucocytes (as discussed in section 3.2 on dietary fatty acids and CHF) should be underlined. As both dietary n-3 fatty acids and moderate alcohol consumption are major characteristics of the Mediterranean diet, it is not surprising to observe that this diet was associated with lower rate of new episodes of CHF in the Lyon Diet Heart Study.60
Thus, any dietary pattern combining a high intake of natural antioxidants, a low intake of saturated fatty acids, a high intake of oleic acid, a low intake of omega-6 fatty acids and a high intake of omega-3 fatty acids would logically produce a highly cardioprotective effect. This is consistent with what we know about the Mediterranean diet pattern38,39 and with the results of the Lyon Diet Heart Study, 19'60'110 and was recently confirmed by epidemiological studies.111,112
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