1

Ser/Thr

Figure 16.5. Formation of O-linked sugars in the ER and GoLGI-complex.

In most cases, synthesis of O-linked oligosaccharides starts with the transfer of GalNAc (from UDP-GalNAc) to Ser or Thr OH-groups by GalNAc-transferase bound to the luminal leaflet of the membrane of the rough ER or cis-Golgi network. After transport of the nascent protein to the trans -Golgi network Gal (from UDP-Gal) (in ¡31 — 3-linkage) and two NANA-residues (from CMP-NANA) are added in sequence.

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