Current Risks Of Platelet Transfusions

The risks for transfusion-transmitted diseases are estimated to be at an historically low rate (Table 2) (6). Nucleic acid testing has substantially decreased the risk of viral infection by shortening the window of infectivity for the hepatitis C virus and the human immunodeficiency virus (HIV).

From: Cancer Drug Discovery and Development Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics Edited by: G. Morstyn, M. A. Foote, and G. J. Lieschke © Humana Press Inc., Totowa, NJ

Table 1

Transfusion of Platelets in the United States"

Table 1

Transfusion of Platelets in the United States"

1989

1992

1994

1997

1999

2001

Concentrates

5146

4688

3582

3396

3036

2614

Apheresis

352

607

714

940

1003

1264

(26%)

(44%)

(54%)

(62%)

(60%)

(74%)

Total transfusions

6958

8330

7866

9037

9054

10,196

a Thousands of units. One apheresis unit = 6 concentrates. Data from refs. 1-3.

a Thousands of units. One apheresis unit = 6 concentrates. Data from refs. 1-3.

Table 2

Some Estimated Risks of Blood Transfusion

Estimated frequency of occurrence per million units (per actual unit)

Infections Viral Hepatitis B Hepatitis C HIV Bacterial Red cells Platelets

Acute hemolytic transfusion reactions Delayed hemolytic transfusion reactions

5-17 (1/60,000-1/200,000) 0.5-1 (1/800,000-1/1.7 x 106)

Data from ref. 6.

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