Contribution To Heart Development

The contribution of the four major embryonic regions (primary heart field, secondary heart field, cardiac neural crest, and proepicardium; Fig. 1) to heart development illustrates the complexity of human heart development. Each of these regions makes a unique contribution to the heart, but they ultimately depend on each other for the creation of a fully functional organ.

An understanding of the mechanisms of human heart development provides clues to the etiology of congenital heart disease. Nevertheless, to date, the genetic regulatory mechanisms of these developmental processes are just starting to be characterized. A molecular review of heart development is outside the scope of this chapter, but several interesting molecular heart reviews have been published (14,52,53). A better understanding of the embryological origins of the heart combined with the characterization of the genes that control heart development (54) may lead to many new clinical applications to treat congenital and adult heart disease.

Your Heart and Nutrition

Your Heart and Nutrition

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