References

Regulation of Myocardial Blood Flow

Duncker, D.J. and Bache, R.J. (2000) Regulation of coronary vasomotor tone under normal conditions and during acute myocardial hypoperfusion. Pharmacol Ther. 86, 87-110. Gorman, M.W., Tune, J.D., Richmond, K.N., and Feigl, E.O. (2000) Feedforward sympathetic coronary vasodilation in exercising dogs. J Appl Physiol. 89, 1892-1902. Ishibashi, Y., Duncker, D.J., Zhang, J., and Bache, R.J. (1998) ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. Circ Res. 82, 346-359.

Myocardial Substrate Selection

Drake, A.J., Haines, J.R., and Noble, M.I. (1980) Preferential uptake of lactate by the normal myocardium in dogs. Cardiovasc Res. 14, 65-72.

Drake-Holland, A.J., Van der Vusse, G.J., Roemen, T.H., et al. (2001) Chronic catecholamine depletion switches myocardium from carbohydrate to lipid utilisation. Cardiovasc Drugs Ther. 15, 111-117.

Lehman, J.J. and Kelly, D.P. (2002) Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol. 29, 339-345.

Glucose and Fatty Acid Metabolism, Tricarboxylic Acid Cycle Function, and Electron Transport Chain Function

Berg, J.M., Stryer, L., and Tymoczko, J.L. (eds.). (2002) Biochemistry, 5th Ed. Freeman, New York, NY.

Murray, R.K., Mayes, P.A., Rodwell, V.W., Granner, D.K.,Granner, D. (eds). (2003) Harper's Illustrated Biochemistry, 26th Ed. Lange Medical Books/McGraw-Hill, New York, NY.

Intermediary Metabolism and Oxidative Phosphorylation

Aimar-Beurton, M., Korzeniewski, B., Letellier, T., Ludinard, S., Mazat, J.P., and Nazaret, C. (2002) Virtual mitochondria: metabolic modelling and control. Mol Biol Rep. 29, 227-232.

Brand, M.D. and Curtis, R.K. (2002) Simplifying metabolic complexity. Biochem Soc Trans. 30, 25-30.

Cortassa, S., Aon, M.A., Marban, E., Winslow, R.L., and O'Rourke, B. (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J. 84, 2734-2755.

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Hochachka, P.W. (2003) Intracellular convection, homeostasis and metabolic regulation. J Exp Biol. 206, 2001-2009.

Korzeniewski, B. (2001) Theoretical studies on the regulation of oxidative phosphorylation in intact tissues. Biochem Biophys Acta. 1504, 31-45.

Korzeniewski, B. (2002) Parallel activation in the ATP supply-demand system lessens the impact of inborn enzyme deficiencies, inhibitors, poisons or substrate shortage on oxidative phosphorylation in vivo. Biophys Chem. 96, 21-31.

Kushmerick, M.J. and Conley, K.E. (2002) Energetics of muscle contraction: the whole is less than the sum of its parts. Biochem Soc Trans. 30, 227-231.

Ludwig, B., Bender, E., Arnold, S., Huttemann, M., Lee, I., and Kadenbach, B. (2001) Cytochrome C oxidase and the regulation of oxidative phosphorylation. Chembiochem. 2, 392-403.

Territo, P.R., Mootha, V.K., French, S.A., and Balaban, R.S. (2000) Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Physiol Cell Physiol. 278, C423-C435.

Zhang, J., Murakami, Y., Zhang, Y., et al. (1999) Oxygen delivery does not limit cardiac performance during high work states. Am J Physiol. 277, H50-H57.

High-Energy Phosphate Shuttles

Dzeja, P.P. and Terzic, A. (2003) Phosphotransfer networks and cellular energetics. J Exp Biol. 206, 2039-2047.

Metabolism During Ischemia

Sambandam, N. and Lopaschuk, G.D. (2003) AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart. Prog Lipid Res. 42, 238-256.

Stanley, W.C., Lopaschuk, G.D., Hall, J.L., and McCormack, J.G. (1997) Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res. 33, 243-257.

Metabolism in Hypertrophied and Failing Myocardium

Lehman, J.J. and Kelly, D.P. (2002) Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol. 29, 339-345.

Liao, R., Jain, M., Cui, L., et al. (2002) Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 106, 2125-2131.

Ning, X.H., Zhang, J., Liu, J., et al. (2000) Signaling and expression for mitochondrial membrane proteins during left ventricular remodeling and contractile failure after myocardial infarction. J Am Coll Cardiol. 36, 282-287.

Young, M.E., Laws, F.A., Goodwin, G.W., and Taegtmeyer, H. (2001) Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem. 276, 44,390-44,395.

Inherited Defects in Myocardial Metabolism

DiMauro, S. and Schon, E.A. (2003) Mitochondrial respiratory-chain diseases. N Engl J Med. 348, 2656-2668.

Roe, C.R., Sweetman, L., Roe, D.S., David, F., and Brunengraber, H. (2002) Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 110, 259-269.

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