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All articles, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher.

Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication.

This publication is printed on acid-free paper. (2)

ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials. Cover design by Patricia F. Cleary.

Cover illustrations: Images were created in the Visible Heart® Laboratory of Professor Iaizzo. (Upper left) An external view of an isolated human heart reanimated in vitro. (The heart was obtained via LifeSource as a r esearch gift from an organ donor whose heart was deemed not viable for transplantation.) (Upper right) An internal view of the apex of the left ventricle of a human heart; note the high degree of trabeculations. (Lower right) Serial endoscopic images showing movements, top-to-bottom, of a tricuspid valve, a pulmonary valve, a mitral valve, and an implanted mechanical aortic valve (left to right, respectively) from within functioning human hearts. (Lower left) Images obtained from an in vitro electrical mapping study of an isolated human heart: an EnSite® 3000 catheter is deployed in the left ventricle and a mapping catheter touches the endocardium. To the right is shown an anatomical isopotential map of excitation (voltage changes) and below it two views of constructed isochronal maps (time sequences of depolarization, anterior and posterior views).

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Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $30.00 is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [1-58829-443-9/05 $30.00].

Printed in China. 10 9 8 7 6 5 4 3 2 1 E-ISBN 1-59259-835-8

Library of Congress Cataloging-in-Publication Data

Handbook of cardiac anatomy, physiology, and devices / edited by Paul A. Iaizzo.

p. cm. -- (Current clinical oncology) Includes bibliographical references and index. ISBN 1-58829-443-9 (alk. paper) 1. Heart--Anatomy--Handbooks, manuals, etc. 2. Heart--Physiology--Handbooks, manuals, etc. 3. Heart--Diseases--Treatment--Handbooks, manuals, etc. I. Iaizzo, Paul A. II. Series: Current clinical oncology (Totowa, N.J.) QM181.H36 2005 616.1'2--dc22

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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