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c Global immune cell ablation

Fig. 2 Immune sensing hypothesis of cytomegalovirus latency control illustrated for pulmonary latency in the BALB/c (H-2d haplotype) mouse model. a Viral gene transcription and immune sensing during latency of wild type mCMV. Most viral genomes, symbolized as episomes associated with cellular histones in a closed higher-order chromatin-like structure, are in a state of MIE locus silencing. Stochastic episodes of open viral chromatin structure at the MIE locus result in IE1 transcription, IE1 protein processing, and MHC class I Ld-restricted presentation of the IE1 peptide 168-YPHFMPTNL-176 to IE1 epitope-specific effector-memory CD8 T cells (IE1-Tem),

Fig. 2 Immune sensing hypothesis of cytomegalovirus latency control illustrated for pulmonary latency in the BALB/c (H-2d haplotype) mouse model. a Viral gene transcription and immune sensing during latency of wild type mCMV. Most viral genomes, symbolized as episomes associated with cellular histones in a closed higher-order chromatin-like structure, are in a state of MIE locus silencing. Stochastic episodes of open viral chromatin structure at the MIE locus result in IE1 transcription, IE1 protein processing, and MHC class I Ld-restricted presentation of the IE1 peptide 168-YPHFMPTNL-176 to IE1 epitope-specific effector-memory CD8 T cells (IE1-Tem),

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