Gonadal Toxicity

In addition to impairment of spermatogenesis, injury to Leydig's cell function is a potential toxic effect of chemotherapy. Elevations of FSH levels were observed in 24 of a cohort of 32 patients who received platinum-based chemotherapy.54 Of these 24 patients, 15 had elevated LH levels. Two patients, each with a remaining testicle, had low testosterone levels. This underscores the problem of compensated (and sometimes uncompensated) Leydig's cell function. Testosterone replacement can be implemented if clinically indicated.

0 0

Post a comment