Role Of Lif In Cancer

Several tumour cell lines and neoplastic cells from various tissues produce LIF and express LIF receptors. However, the functional significance of either LIF or LIFR in human neoplasia is not fully understood. LIF can stimulate growth, induce differentiation, or trigger apoptotic cell death of various tumour cells (1,141,150,151) and data on the mechanisms controlling this diverse array of effects are scanty. Results of in vivo animal trials shed light on some of the possible roles of LIF in...

Kluwer Academic Publishers

NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN 0-306-48399-8 Print ISBN 0-7923-7141-0 New York, Boston, Dordrecht, London, Moscow Print 2001 Kluwer Academic Publishers Dordrecht No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at and Kluwer's eBookstore at http kluweronline.com http...

The Role Of Fibroblast Growth Factors In Prostate Cancer

Prostate cancer, which is the most commonly diagnosed malignant tumour in the Western world, could be cured with radical prostatectomy in its early stages. All other prostate tumours need to be treated with androgen ablation therapy. This therapy is only palliative and nearly all tumours progress to the therapy-refractory stage. Various experimental treatments for advanced disease have been tried with little success. Progression of prostate cancer involves alterations in expression and function...