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A549 + 293

A549 + 293mda7

Time (days)

Fig. 6. Antiangiogenic activity of MDA-7/IL-24 in vivo. MDA-7/IL-24 systemically inhibits tumor growth and vascularization. Subcutaneous A549 lung tumor xenografts were established in nude mice in the lower right flank. When the tumors were measurable, Matrigel encapsulated 293 or 293-mda7 cells were implanted in the upper right flank. Tumor growth was monitored regularly for 3 wk. A significant inhibition of tumor growth was observed in animals implanted with Matrigel encapsulated 293-mda7 cells compared with animals implanted with Matrigel encapsulated 293 cells. Representative tumors are shown in upper panel and tumor growth kinetics are shown in lower panel.

Time (days)

Fig. 6. Antiangiogenic activity of MDA-7/IL-24 in vivo. MDA-7/IL-24 systemically inhibits tumor growth and vascularization. Subcutaneous A549 lung tumor xenografts were established in nude mice in the lower right flank. When the tumors were measurable, Matrigel encapsulated 293 or 293-mda7 cells were implanted in the upper right flank. Tumor growth was monitored regularly for 3 wk. A significant inhibition of tumor growth was observed in animals implanted with Matrigel encapsulated 293-mda7 cells compared with animals implanted with Matrigel encapsulated 293 cells. Representative tumors are shown in upper panel and tumor growth kinetics are shown in lower panel.

implanted to 293-mda7 cells, suggesting that the protein had no toxic side effects. These results demonstrated MDA-7 protein systemically inhibited tumor growth by inhibiting tumor angiogenesis. Furthermore, our results establish a direct antiangiogenic activity for MDA-7/IL-24.

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