The Revised Authoritative Guide To Vaccine Legal Exemptions

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Fig. 3. Differential viral recovery. Vaccinia titers recovered from brain and tumor 4 d after injection of virus intraperitoneally in MC38 subcutaneous tumor bearing mice. Data represents median of 5 values. No recoverable titers are seen in brain tissue form the double deleted virus (VVDDEGFP) whereas the tumor has equivalent titers to wild type.

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29. Chakrabarti S, Sisler JR, Moss B. Compact, synthetic, vaccinia virus early/late promoter for protein expression. BioTechniques 1997;23:1094-1097.

30. Earl PL, Moss B. Expression of Proteins in Mammalian Cells Using Vaccinia Viral Vectors. In: Current Protocols in Molecular Biology. Ausubel FM, Kinston RE, Moore DD, Seidman JG, Smith JA et al., eds. New York: Green/Wiley Interscience, 1998:16.

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37. Enserink M. Bioterrorism. In search of a kindler, gentler vaccine. Science 2002:296:1594.

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42. Alcami A, Smith GL. The vaccinia virus soluble alpha/beta interferon(IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN. J Virol 2000;74(23):11,230-11,239.

43. Colamonici OR, Domanski P, Sweitzer SM, Larner A, Buller RM. Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks and interferon alpha transmembrane signaling. J Biol Chem 1995;270(27):15,974-15,978.

44. Alcami A, Smith GL. The vaccinia virus soluble interferon-gamma receptor is homodimer. J Gen Virol 2002;83:545-549.

45. Seet BT, McFadden G. Viral chemokine-binding proteins. J Leukoc Biol 2002;72(1):24-34.

46. Alcami A, Symons JA, Collins PD, Williams TJ, Smith GL. Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus. J Immunol 1998;160(2):624-633.

47. Mahalingam S, Karupiah G. Modulation of chemokines by poxvirus infections. Curr Opin Immunol 2000;12(4):409-412.

48. Smith VP, Byant NA, Alcami A. Ectromelia, vaccinia and coxpox viruses encode secreted interleukin-18 binding proteins. J Gen Virol 2000;81:1223-1230.

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52. Van Den Broek M, Bachmann MF, Kohler G, et al. IL-4 and IL-10 antagonize IL-12 mediated protection against acute vaccinia virus infection with a limited role of IFN gamma and nitric oxide synthetase 2. J Immunol 2000;164:371-378.

53. Deonarain R, Alcami A, Alexiou M, Dallman MJ, Gewert DR, Porter AC. Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol 2003;84:1962-1972.

54. Gherardi MM, Ramirez JC, Esteban M. IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system. J GenVirol 2003;84:1961-1972.

55. Eder JP, Kantoff PW, Roper K. A phase I trial of recombinant vaccinia virus expressing prostate-specific antigen in advanced prostate cancer. Clin Cancer Res 2000;6:1632-1638.

56. Marshall JL, Hoyer RJ, Toomey MA, et al. Phase I study in advanced cancer patients of a diversified prime and boost vaccination protocol using recombinant vaccinia virus and recombinant non replicating avipox virus to elicit anti-carcinoembroyinic antigen immune responses. J Clin Oncol 2000;18:3964-3973.

57. Greiner JW, Zeytin H, Anver MR, Schlom J. Vaccine based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmu-nity. Cancer Res 2000;62:6944-6951.

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60. Rochlitz C, Figlin R, Squiban P, et al. Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen specific immunotherapy in patients with MUC 1 advanced cancer. J Gene Med 2003;5:690-699.

61. McCart JA, Ward JM, Lee J, et al. Systemic cancer therapy with a tumor selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes. Cancer Res 2001;61:8751-8757.

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63. Mullen JT, Tanabe KT. Viral Oncolysis for Malignant Liver Tumors. Annal Surg Oncol 2003;10:596-605.

64. Gnant M, Puhlman MD, Bartlett DL, Alexander HR. Regional versus Systemic Delivery of Recombinant Vaccinia Virus as Suicide Gene Therapy for Murine Liver Metastases. Annal Surg 1999;230: 352-361.

65. Fodor I, Timiryasova T, Denes B, Yoshida J, Ruckle H, Lilly M. Vaccinia virus-mediated p53 gene therapy of bladder cancer in an orthotopic murine model. J Urol 2005;173:604-609.

66. Haghighat P, Timiryasova T, Chen B, Kajioka E, Gridley DS, Fodor I. Antitumor effect of Il-2, p53, and bax gene transfer in C6 glioma cells. Anticancer Res 2000;20:1337-1342.

67. Adams M, Borysiewicz L, Fiander A, et al. Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer. Vaccine 2001 21;19(17-19):2549-2456.

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