Glucose6phosphate Dehydrogenase Deficiency

Nonspherocytic Hemolytic Anemia

There are a limited number of inherited disorders of red cells related to biochemical deficiencies. Glucoses-phosphate dehydrogenase G6PD deficiency represents a fascinating and far-reaching disorder that has at its core a metabolic misstep. G6PD is the catalyst in the first stages of the oxidative portion of the red cell's metabolism and a key player is the phosphogluconate pathway, whose role it is to keep glutathione in the reduced state. Glutathione is the chief red cell antioxidant and...

Case Study Insulin Resistance

A 30-year-old woman was referred to the hospital for evaluation. She presented with a history of multiple spontaneous abortions. She is currently complaining of pain and swelling in her left thigh. Her family history and her past medical history were unremarkable. The patient is currently on oral contraceptives. The patient's laboratory results were as follows 8.0 X 109 L (Reference range, 4.4 to 11.0) 4.7 X 1012 L (Reference range, 4.1 to 5.1) 14.0 g dL (Reference range, 12.3 to 15.3) 43...

Table 202 O Platelet Estimate From Peripheral Smear

Platelets per X100 Field Platelet Count Estimate Figure 20.7 Three zones of wedge preparation. 1. WBCs should contain a blue nucleus along with a lighter staining cytoplasm. 2. RBCs should have good quality of color ranging from buff pink to orange. 3. Platelets should be blue with granules and no nucleus. 1. Place a well-stained slide on the stage of the microscope, smear side up, and focus using the low-power objective (X10). 2. Check to see if there are good counting areas available free of...