Chapter

The Macrocytic Anemias, 85

Betty Ciesla

The Macrocytic Anemias and the

Megaloblastic Process, 86 The Red Cell Precursors in Megaloblastic

Anemia, 86 Ineffective Erythropoiesis in Megaloblastic Anemia, 86 Vitamin B12 and Folic Acid: Their Role in

DNA Synthesis, 87 Nutritional Requirements, Transport, and

Metabolism of Vitamin B12 and Folic Acid, 87 12

Incorporating Vitamin B12 Into the Bone

Marrow, 88 Clinical Features of Patients With

Megaloblastic Anemia, 88 Hematological Features of Megaloblastic

Anemias, 88 Pernicious Anemia as a Subset of

Megaloblastic Anemias, 89 Vitamin B12 and Folic Acid Deficiency,

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