Hemoglobin Function and Principles of Hemolysis

Extravascular Hemolysis

Betty Ciesla

Hemoglobin Structure and Synthesis

Types of Hemoglobin Hemoglobin Function Abnormal Hemoglobins

The Hemolytic Process

Types of Hemolysis Laboratory Evidence of Hemolysis The Physiology of Hemolysis

Terminology Relevant to the Hemolytic Anemias

Objectives

After completing this chapter, the student will be able to:

1. Identify the components of hemoglobin.

2. Define the normal structural elements related to hemoglobin synthesis.

3. Describe hemoglobin function.

4. Describe the origin of hemoglobin synthesis in erythroid precursors.

5. List the normal adult hemoglobins.

6. Describe the chemical configuration and percentages of the normal adult hemoglobins, Hgb A, Hgb A2, and Hgb F

7. Relate the shift from fetal hemoglobin to adult hemoglobin in terms of fetal to adult development.

8. Outline the steps involved in oxygen delivery and the elimination of carbon dioxide.

9. Describe the oxygen dissociation curve in general terms.

10. Differentiate the abnormal hemoglobins in terms of toxicity and oxygen capacity.

11. Describe hemolysis in terms of its effect on the bone marrow, blood smear, and blood chemistry.

12. Define extravascular hemolysis with respect to organ of origin and laboratory diagnosis.

13. Define intravascular hemolysis with respect to organs affected and laboratory diagnosis.

14. Recall the terminologies used to classify the hemolytic anemias.

52 Part I • Basic Hematology Principles

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