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Part II • Red Cell Disorders

Review Questions

1. Which bone marrow changes are most prominent in the megaloblastic anemias?

b. Hypocellular bone marrow c. Asynchrony in the red cell precursors d. Shaggy cytoplasm of the red cell precursors

2. Which morphological changes in the peripheral smear are markers for megaloblastic anemias?

a. Oval macrocytes and hypersegmented neu-trophils b. Oval and hypochromic macrocytes c. Pappenheimer bodies and hypochromic micro-cytes d. Dimorphic red cells and Howell-Jolly bodies

3. Which is the most common vitamin deficiency in the United States?

a. Vitamin A

b. Folic acid c. Calcium d. Vitamin B12

4. Which of the following group of symptoms is particular to patients with megaloblastic anemia?

a. Pallor and dyspnea b. Jaundice and hemoglobinuria c. Difficulty in walking and mental confusion d. Pica and fatigue

5. Which one of the following substances is necessary for vitamin B12 to be absorbed?

a. Transferrin b. Erythropoietin c. Intrinsic factor d. Cubilin

6. Which of the following clinical findings is indicative of intramedullary hemolysis in megaloblastic processes?

a. Increased red count b. Increased hemoglobin c. Decreased bilirubin d. Increased LDH

7. Which of the following adequately describes the pathophysiology of the megaloblastic anemias?

a. Lack of DNA synthesis b. Defect in globin synthesis c. Defect in iron metabolism d. Excessive iron loading

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